The Role of Adiposity in Atrial Fibrillation Pathogenesis - An Area of Growing Scientific and Clinical Interest

Overview

Journal Heart Rhythm O2

Date 2021 Aug 25

PMID 34430936

Citations 1

Authors

Yaacoub Chahine

Nazem Akoum

Affiliations

Soon will be listed here.

Citing Articles

Atrial fibrillation substrate and impaired left atrial function: a cardiac MRI study.

Chahine Y, Chamoun N, Kassar A, Bockus L, Macheret F, Akoum N Europace. 2024; 26(11).

PMID: 39523754 PMC: 11551228. DOI: 10.1093/europace/euae258.

References

Nalliah C, Bell J, Raaijmakers A, Waddell H, Wells S, Bernasochi G . Epicardial Adipose Tissue Accumulation Confers Atrial Conduction Abnormality. J Am Coll Cardiol. 2020; 76(10):1197-1211. DOI: 10.1016/j.jacc.2020.07.017. View

Ishii Y, Abe I, Kira S, Harada T, Takano M, Oniki T . Detection of fibrotic remodeling of epicardial adipose tissue in patients with atrial fibrillation: Imaging approach based on histological observation. Heart Rhythm O2. 2021; 2(4):311-323. PMC: 8369308. DOI: 10.1016/j.hroo.2021.05.006. View

Foy A, Mandrola J, Liu G, Naccarelli G . Relation of Obesity to New-Onset Atrial Fibrillation and Atrial Flutter in Adults. Am J Cardiol. 2018; 121(9):1072-1075. DOI: 10.1016/j.amjcard.2018.01.019. View

Pokushalov E, Kozlov B, Romanov A, Strelnikov A, Bayramova S, Sergeevichev D . Long-Term Suppression of Atrial Fibrillation by Botulinum Toxin Injection Into Epicardial Fat Pads in Patients Undergoing Cardiac Surgery: One-Year Follow-Up of a Randomized Pilot Study. Circ Arrhythm Electrophysiol. 2015; 8(6):1334-41. DOI: 10.1161/CIRCEP.115.003199. View

Iacobellis G, Corradi D, Sharma A . Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart. Nat Clin Pract Cardiovasc Med. 2005; 2(10):536-43. DOI: 10.1038/ncpcardio0319. View

Fox C, Massaro J, Hoffmann U, Pou K, Maurovich-Horvat P, Liu C . Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation. 2007; 116(1):39-48. DOI: 10.1161/CIRCULATIONAHA.106.675355. View

Wong C, Sullivan T, Sun M, Mahajan R, Pathak R, Middeldorp M . Obesity and the Risk of Incident, Post-Operative, and Post-Ablation Atrial Fibrillation: A Meta-Analysis of 626,603 Individuals in 51 Studies. JACC Clin Electrophysiol. 2018; 1(3):139-152. DOI: 10.1016/j.jacep.2015.04.004. View

Haemers P, Hamdi H, Guedj K, Suffee N, Farahmand P, Popovic N . Atrial fibrillation is associated with the fibrotic remodelling of adipose tissue in the subepicardium of human and sheep atria. Eur Heart J. 2015; 38(1):53-61. DOI: 10.1093/eurheartj/ehv625. View

Singh N, Singh H, Khanijoun H, Iacobellis G . Echocardiographic assessment of epicardial adipose tissue--a marker of visceral adiposity. Mcgill J Med. 2008; 10(1):26-30. PMC: 2323549. View

10.

Gaborit B, Venteclef N, Ancel P, Pelloux V, Gariboldi V, Leprince P . Human epicardial adipose tissue has a specific transcriptomic signature depending on its anatomical peri-atrial, peri-ventricular, or peri-coronary location. Cardiovasc Res. 2015; 108(1):62-73. DOI: 10.1093/cvr/cvv208. View

11.

Mahajan R, Lau D, Brooks A, Shipp N, Manavis J, Wood J . Electrophysiological, Electroanatomical, and Structural Remodeling of the Atria as Consequences of Sustained Obesity. J Am Coll Cardiol. 2015; 66(1):1-11. DOI: 10.1016/j.jacc.2015.04.058. View

12.

Wong C, Sun M, Odutayo A, Emdin C, Mahajan R, Lau D . Associations of Epicardial, Abdominal, and Overall Adiposity With Atrial Fibrillation. Circ Arrhythm Electrophysiol. 2016; 9(12). DOI: 10.1161/CIRCEP.116.004378. View

13.

Abe I, Teshima Y, Kondo H, Kaku H, Kira S, Ikebe Y . Association of fibrotic remodeling and cytokines/chemokines content in epicardial adipose tissue with atrial myocardial fibrosis in patients with atrial fibrillation. Heart Rhythm. 2018; 15(11):1717-1727. DOI: 10.1016/j.hrthm.2018.06.025. View

14.

Cozma D, Popescu B, Lighezan D, Lucian P, Mornos C, Ginghina C . Left atrial remodeling: assessment of size and shape to detect vulnerability to atrial fibrillation. Pacing Clin Electrophysiol. 2007; 30 Suppl 1:S147-50. DOI: 10.1111/j.1540-8159.2007.00626.x. View

15.

Antonopoulos A, Sanna F, Sabharwal N, Thomas S, Oikonomou E, Herdman L . Detecting human coronary inflammation by imaging perivascular fat. Sci Transl Med. 2017; 9(398). DOI: 10.1126/scitranslmed.aal2658. View

16.

Thanassoulis G, Massaro J, ODonnell C, Hoffmann U, Levy D, Ellinor P . Pericardial fat is associated with prevalent atrial fibrillation: the Framingham Heart Study. Circ Arrhythm Electrophysiol. 2010; 3(4):345-50. PMC: 2953855. DOI: 10.1161/CIRCEP.109.912055. View