Aggressive Angiomyxoma of Vulva in 28-years Old Patient: A Case Report of Second Recurrence

Overview

Journal Ann Med Surg (Lond)

Publisher Wolters Kluwer

Specialty Medical Education

Date 2021 Aug 25

PMID 34429960

Citations 4

Authors

Mehrangiz Zamani

Mina Mollabashi

Narges Mehrabi

Shima Alizadeh

Affiliations

Soon will be listed here.

Abstract

Introduction: Aggressive angiomyxoma is an uncommon mesenchymal tumor in women who are in reproductive age, that occurring in the pelvis and perineal zone with a high risk of local infiltration and recurrence.

Case Presentation: We describe a case of a 28-year-old woman with a huge recurrent vulvar aggressive angiomyxoma.

Clinical Discussion: Our patients underwent surgery and tumor resection for two times but had relapsed every 2 years through 5 years and finally she underwent total vulvectomy. The patient received Decapeptide for 3 months to prevent tumor recurrence after surgery and to date,there has been no evidence of local recurrence.

Conclusion: Aggressive angiomyxoma is a rare tumor with high recurrence rate. The best treatment is surgical resection by experienced Gyn-oncologist in teamwork and territory Hospital.

Citing Articles

Aggressive angiomyxoma of the vagina: A case report and literature review.

Yu B, Choi W, Cho D, Lee N Medicine (Baltimore). 2025; 104(4):e41287.

PMID: 39854765 PMC: 11771726. DOI: 10.1097/MD.0000000000041287.

Massive aggressive angiomyxoma of ischioanal region with relapse: A case report.

Naderzadeh A, Attarbashi A, Pourali L, Ansari M, Abdollahi A Int J Reprod Biomed. 2024; 22(4):329-334.

PMID: 39035628 PMC: 11255467. DOI: 10.18502/ijrm.v22i4.16394.

Aggressive Angiomyxoma of the Lower Female Genital Tract: A Review of the MITO Rare Tumors Group.

Dellino M, Magazzino F, Domenici L, Cicogna S, Miano S, Pignata S Cancers (Basel). 2024; 16(7).

PMID: 38611053 PMC: 11011140. DOI: 10.3390/cancers16071375.

Characteristics and treatment strategies of aggressive angiomyxoma in women: A retrospective review of 87 cases.

Wang Y, Bu X, Liu Y, Xing Y, Tong Q Front Surg. 2023; 10:966971.

PMID: 37139188 PMC: 10149767. DOI: 10.3389/fsurg.2023.966971.

Aggressive Angiomyxoma of the Vulva: Which Is the Best Management Strategy? Description of a Case Report and Review of Literature of the Last Ten Years.

Gulino F, Gulisano M, Ettore C, Giorlandino A, Russo E, Ettore G J Clin Med. 2023; 12(5).

PMID: 36902513 PMC: 10003322. DOI: 10.3390/jcm12051726.

References

Sun N, Li W . Aggressive angiomyxoma of the vulva: case report and literature review. J Int Med Res. 2010; 38(4):1547-52. DOI: 10.1177/147323001003800439. View

Kura M, Jindal S, Khemani U . Aggressive angiomyxoma of the vulva: An uncommon entity. Indian Dermatol Online J. 2012; 3(2):128-30. PMC: 3481881. DOI: 10.4103/2229-5178.96712. View

Poirier M, Fraser R, Meterissian S . Case 1. Aggressive angiomyxoma of the pelvis: response to luteinizing hormone-releasing hormone agonist. J Clin Oncol. 2003; 21(18):3535-6. DOI: 10.1200/JCO.2003.10.174. View

Outwater E, Marchetto B, Wagner B, Siegelman E . Aggressive angiomyxoma: findings on CT and MR imaging. AJR Am J Roentgenol. 1999; 172(2):435-8. DOI: 10.2214/ajr.172.2.9930798. View

Siassi R, Papadopoulos T, Matzel K . Metastasizing aggressive angiomyxoma. N Engl J Med. 1999; 341(23):1772. DOI: 10.1056/nejm199912023412315. View

Sereda D, Sauthier P, Hadjeres R, Funaro D . Aggressive angiomyxoma of the vulva: a case report and review of the literature. J Low Genit Tract Dis. 2008; 13(1):46-50. DOI: 10.1097/LGT.0b013e318180436f. View

Smith H, WORRELL R, Smith A, Dorin M, Rosenberg R, Bartow S . Aggressive angiomyxoma of the female pelvis and perineum: review of the literature. Gynecol Oncol. 1991; 42(1):79-85. DOI: 10.1016/0090-8258(91)90235-w. View

Mathieson A, Chandrakanth S, Yousef G, Wadden P . Aggressive angiomyxoma of the pelvis: a case report. Can J Surg. 2007; 50(3):228-9. PMC: 2384290. View

Fetsch J, Laskin W, Lefkowitz M, Kindblom L, Meis-Kindblom J . Aggressive angiomyxoma: a clinicopathologic study of 29 female patients. Cancer. 1996; 78(1):79-90. DOI: 10.1002/(SICI)1097-0142(19960701)78:1<79::AID-CNCR13>3.0.CO;2-4. View

10.

Behranwala K, Thomas J . 'Aggressive' angiomyxoma: a distinct clinical entity. Eur J Surg Oncol. 2003; 29(7):559-63. DOI: 10.1016/s0748-7983(03)00104-5. View

11.

Alameda F, Munne A, Baro T, Iglesias M, Condom E, Lloreta-Trull J . Vulvar angiomyxoma, aggressive angiomyxoma, and angiomyofibroblastoma: an immunohistochemical and ultrastructural study. Ultrastruct Pathol. 2006; 30(3):193-205. DOI: 10.1080/01913120500520911. View

12.

Gungor T, Zengeroglu S, Kaleli A, Kuzey G . Aggressive angiomyxoma of the vulva and vagina. A common problem: misdiagnosis. Eur J Obstet Gynecol Reprod Biol. 2003; 112(1):114-6. DOI: 10.1016/s0301-2115(03)00270-7. View

13.

Agha R, Franchi T, Sohrabi C, Mathew G, Kerwan A . The SCARE 2020 Guideline: Updating Consensus Surgical CAse REport (SCARE) Guidelines. Int J Surg. 2020; 84:226-230. DOI: 10.1016/j.ijsu.2020.10.034. View

14.

Brooks S, Balidimos I, Reuter K, Khan A . Virtual consult--aggressive angiomyxoma of the vulva: impact of GnRH agonists. Medscape Womens Health. 1998; 3(3):4. View

15.

Amin A, El Badawy S, Bull A . Aggressive angiomyxoma of the vulva. J Obstet Gynaecol. 2013; 33(3):325-6. DOI: 10.3109/01443615.2012.731456. View

16.

van Roggen J, Hogendoorn P, Fletcher C . Myxoid tumours of soft tissue. Histopathology. 1999; 35(4):291-312. DOI: 10.1046/j.1365-2559.1999.00835.x. View

17.

Blandamura S, Cruz J, Faure Vergara L, Machado Puerto I, Ninfo V . Aggressive angiomyxoma: a second case of metastasis with patient's death. Hum Pathol. 2003; 34(10):1072-4. DOI: 10.1053/s0046-8177(03)00419-2. View