In Vivo Hemostatic Activity of Jatropha Mollissima: A Triple-Blinded, Randomized, Controlled Trial in an Animal Model

Overview

Journal Eur J Dent

Publisher Thieme

Specialty Dentistry

Date 2021 Aug 24

PMID 34428842

Citations 2

Authors

Maria Vitoria Oliveira Dantas

Paula Lima Nogueira

Filipe de Oliveira Lima

Denis Candeia Pereira Oliveira

Emanuelly Nara Severiano Gomes

Jose Filipe Bacalhau Rodrigues

Solomon Kweku Sagoe Amoah

Rosana Araujo Rosendo

Elizandra Silva da Penha

Antonio Flavio Medeiros Dantas

Marcus Vinicius Lia Fook

Rogerio Lacerda-Santos

Luanna Abilio Diniz Melquiades de Medeiros

Affiliations

Soon will be listed here.

Abstract

Objective: The objective of this study was to evaluate the hemostatic activity of the sap from (Pohl) Baill. in rats.

Materials And Methods: Twenty-four Wistar rats were randomized into four groups ( = 6): the JM25 and JM40 groups were treated with ethanolic extract from the sap of , in a concentration of 25 and 40 mg·mL, respectively; the MO group was treated with Monsel's solution and the control group SC with a 0.9% sodium chloride solution.

Statistical Analysis: Data were submitted to the Kurskal-Wallis' test, followed by Dunn's post hoc ( < 0.05).

Results: There was a significant reduction in the bleeding time of the group from the JM25 extract ( = 0.001) when compared with MO and SC. There were no statistically significant differences between groups JM25 and JM40 ( > 0.05). The JM25 group did not present rebleeding, a result significantly different from the MO group ( = 0.001). Monsel's solution showed significant bleeding, six times greater than the control group SC.

Conclusion: The extract, in the concentration of 25 mg·mL, showed the highest hemostatic efficiency and was found to be a promising biomaterial for the elaboration of a hemostatic product.

Citing Articles

Chitosan-PEG Gels Loaded with (Pohl) Baill. Ethanolic Extract: An Efficient and Effective Biomaterial in Hemorrhage Control.

Rodrigues J, Queiroz J, Medeiros R, Santos R, Fialho D, Neto J Pharmaceuticals (Basel). 2023; 16(10).

PMID: 37895870 PMC: 10609772. DOI: 10.3390/ph16101399.

Chitosan/Gelatin Scaffolds Loaded with Extract as Potential Skin Tissue Engineering Materials.

de Souza M, da Silva H, Rodrigues J, Macedo M, de Sousa W, Barbosa R Polymers (Basel). 2023; 15(3).

PMID: 36771903 PMC: 9921636. DOI: 10.3390/polym15030603.

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