Association of Atopic Dermatitis with an Increased Risk of Systemic Lupus Erythematosus: A Systematic Review and Meta-analysis

Overview

Journal J Postgrad Med

Specialty General Medicine

Date 2021 Aug 24

PMID 34427279

Citations 3

Authors

B Ponvilawan

N Charoenngam

W Wongtrakul

P Ungprasert

Affiliations

Soon will be listed here.

Abstract

Context: Previous studies on the association between atopic dermatitis (AD) and systemic lupus erythematosus (SLE) have yielded inconsistent results.

Aims: To investigate the relationship between atopic dermatitis and systemic lupus erythematosus.

Settings And Design: Systematic review and meta-analysis.

Materials And Methods: A systematic review was conducted on EMBASE and MEDLINE databases from inception to March 2020 using a search strategy that consisted of terms related to AD and SLE. Eligible study must be either cohort or case-control study. For cohort studies, they must include patients with AD and comparators without AD, then follow them for incident SLE. For case-control studies, they must include cases with SLE and controls without SLE and examine their prior history of AD.

Statistical Analysis Used: Meta-analysis of the studies was performed using a random-effect, generic inverse variance method to combine effect estimate and standard error. Funnel plot was used to assess publication bias.

Results: A total of 21,486 articles were retrieved. After two rounds of review by three investigators, six case-control studies were qualified for the meta-analysis. The case-control study meta-analysis found a significantly increased odds of SLE among patients with AD with the pooled odds ratio of 1.46 (95% CI, 1.05-2.04).

Conclusions: A significant association between AD and increased odds of SLE was observed by this systematic review and meta-analysis.

Citing Articles

Systemic lupus erythematosus and Atopic dermatitis: A two sample Mendelian randomization study.

Xia Z, Liu J, Zu Y Clin Rheumatol. 2024; 43(4):1311-1317.

PMID: 38349447 DOI: 10.1007/s10067-024-06900-z.

Risk factors of systemic lupus erythematosus: an overview of systematic reviews and Mendelian randomization studies.

Xiao X, Chen Q, Shi Y, Li L, Hua C, Zheng H Adv Rheumatol. 2023; 63(1):42.

PMID: 37596678 DOI: 10.1186/s42358-023-00323-1.

Understanding Ocular Findings and Manifestations of Systemic Lupus Erythematosus: Update Review of the Literature.

Lubon W, Lubon M, Kotyla P, Mrukwa-Kominek E Int J Mol Sci. 2022; 23(20).

PMID: 36293119 PMC: 9603180. DOI: 10.3390/ijms232012264.

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