Delta-Aminolevulinic Acid Dehydratase Isozymes and Lead Toxicity

Overview

Journal Ann N Y Acad Sci

Specialty Science

Date 1987 Jan 1

PMID 3442386

Citations 24

Authors

K H Astrin

D F Bishop

J G Wetmur

B Kaul

B DAVIDOW

R J Desnick

Affiliations

Soon will be listed here.

Abstract

ALAD is a zinc metalloenzyme whose inhibition by lead is the first and most sensitive indicator of lead exposure and whose decreased activity has been implicated in the pathogenesis of lead poisoning. This heme biosynthetic enzyme is encoded by a gene located at chromosome 9q34, which has two codominant alleles, ALAD1 and ALAD2. The occurrence of two frequent alleles for ALAD stimulated an investigation into the possible pharmacogenetic role of the enzyme polymorphism in lead poisoning. In a New York City population at high risk for lead exposure, individuals heterozygous or homozygous for the less common allele, ALAD2, had blood lead levels greater than or equal to 30 micrograms/dl more frequently than expected. These findings suggest a potential genetic susceptibility to lead poisoning in individuals with the ALAD 1-2 and 2-2 phenotypes.

Citing Articles

Assessment of Heavy Metals and Related Impacts on Antioxidants and Physiological Parameters in Oil Refinery Workers in Iraq.

Ajeel M, Ajeel A, Nejres A, Salih R J Health Pollut. 2021; 11(31):210907.

PMID: 34434599 PMC: 8383791. DOI: 10.5696/2156-9614-11.31.210907.

Delta-Aminolevulinic Acid Dehydratase, Low Blood Lead Levels, Social Factors, and Intellectual Function in an Afro-Brazilian Children Community.

Bah H, Dos Anjos A, Gomes-Junior E, Bandeira M, de Carvalho C, Dos Santos N Biol Trace Elem Res. 2021; 200(2):447-457.

PMID: 33723800 DOI: 10.1007/s12011-021-02656-8.

Smelting Remains a Public Health Risk Nearly a Century Later: A Case Study in Pueblo, Colorado, USA.

Diawara M, Shrestha S, Carsella J, Farmer S Int J Environ Res Public Health. 2018; 15(5).

PMID: 29735921 PMC: 5981971. DOI: 10.3390/ijerph15050932.

Synthesis, delivery and regulation of eukaryotic heme and Fe-S cluster cofactors.

Barupala D, Dzul S, Riggs-Gelasco P, Stemmler T Arch Biochem Biophys. 2016; 592:60-75.

PMID: 26785297 PMC: 4784227. DOI: 10.1016/j.abb.2016.01.010.

Evaluation of Low Blood Lead Levels and Its Association with Oxidative Stress in Pregnant Anemic Women: A Comparative Prospective Study.

Tiwari A, Mahdi A, Zahra F, Sharma S, Negi M Indian J Clin Biochem. 2015; 27(3):246-52.

PMID: 26405382 PMC: 4577501. DOI: 10.1007/s12291-012-0202-2.