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Computational Theory-driven Studies of Reinforcement Learning and Decision-making in Addiction: What Have We Learned?

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Date 2021 Aug 23
PMID 34423103
Citations 22
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Abstract

Computational psychiatry provides a powerful new approach for linking the behavioral manifestations of addiction to their precise cognitive and neurobiological substrates. However, this emerging area of research is still limited in important ways. While research has identified features of reinforcement learning and decision-making in substance users that differ from health, less emphasis has been placed on capturing addiction cycles/states dynamically, within-person. In addition, the focus on few behavioral variables at a time has precluded more detailed consideration of related processes and heterogeneous clinical profiles. We propose that a longitudinal and multidimensional examination of value-based processes, a type of dynamic "computational fingerprint", will provide a more complete understanding of addiction as well as aid in developing better tailored and timed interventions.

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References
1.
Groman S . Investigating the computational underpinnings of addiction. Neuropsychopharmacology. 2019; 44(13):2149-2150. PMC: 6897857. DOI: 10.1038/s41386-019-0412-x. View

2.
Hogarth L . Addiction is driven by excessive goal-directed drug choice under negative affect: translational critique of habit and compulsion theory. Neuropsychopharmacology. 2020; 45(5):720-735. PMC: 7265389. DOI: 10.1038/s41386-020-0600-8. View

3.
Voon V, Morris L, Irvine M, Ruck C, Worbe Y, Derbyshire K . Risk-taking in disorders of natural and drug rewards: neural correlates and effects of probability, valence, and magnitude. Neuropsychopharmacology. 2014; 40(4):804-12. PMC: 4305336. DOI: 10.1038/npp.2014.242. View

4.
Montague P, Dolan R, Friston K, Dayan P . Computational psychiatry. Trends Cogn Sci. 2011; 16(1):72-80. PMC: 3556822. DOI: 10.1016/j.tics.2011.11.018. View

5.
Ersche K, Gillan C, Jones P, Williams G, Ward L, Luijten M . Carrots and sticks fail to change behavior in cocaine addiction. Science. 2016; 352(6292):1468-71. PMC: 5144994. DOI: 10.1126/science.aaf3700. View