LncRNAs As Therapeutic Targets and Potential Biomarkers for Lipid-Related Diseases

Overview

Journal Front Pharmacol

Date 2021 Aug 23

PMID 34421622

Citations 10

Authors

Shi-Feng Huang

Xiao-Fei Peng

Lianggui Jiang

Ching Yuan Hu

Wen-Chu Ye

Affiliations

Soon will be listed here.

Abstract

Lipid metabolism is an essential biological process involved in nutrient adjustment, hormone regulation, and lipid homeostasis. An irregular lifestyle and long-term nutrient overload can cause lipid-related diseases, including atherosclerosis, myocardial infarction (MI), obesity, and fatty liver diseases. Thus, novel tools for efficient diagnosis and treatment of dysfunctional lipid metabolism are urgently required. Furthermore, it is known that lncRNAs based regulation like sponging microRNAs (miRNAs) or serving as a reservoir for microRNAs play an essential role in the progression of lipid-related diseases. Accordingly, a better understanding of the regulatory roles of lncRNAs in lipid-related diseases would provide the basis for identifying potential biomarkers and therapeutic targets for lipid-related diseases. This review highlighted the latest advances on the potential biomarkers of lncRNAs in lipid-related diseases and summarised current knowledge on dysregulated lncRNAs and their potential molecular mechanisms. We have also provided novel insights into the underlying mechanisms of lncRNAs which might serve as potential biomarkers and therapeutic targets for lipid-related diseases. The information presented here may be useful for designing future studies and advancing investigations of lncRNAs as biomarkers for diagnosis, prognosis, and therapy of lipid-related diseases.

Citing Articles

Importance of long non-coding RNAs in the pathogenesis, diagnosis, and treatment of myocardial infarction.

Zolfaghari Dehkharghani M, Mousavi S, Kianifard N, Fazlzadeh A, Parsa H, Tavakoli Pirzaman A Int J Cardiol Heart Vasc. 2024; 55:101529.

PMID: 39498345 PMC: 11532444. DOI: 10.1016/j.ijcha.2024.101529.

The Role of Selected lncRNAs in Lipid Metabolism and Cardiovascular Disease Risk.

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A Holistic Analysis of Alzheimer's Disease-Associated lncRNA Communities Reveals Enhanced lncRNA-miRNA-RBP Regulatory Triad Formation Within Functionally Segregated Clusters.

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