CHARACTERIZATION OF ALVEOLAR SOFT PART SARCOMA OF THE TONGUE: A CLINICO-PATHOLOGIC STUDY AND SCOPING REVIEW

Overview

Journal Ann Ib Postgrad Med

Specialty General Medicine

Date 2021 Aug 23

PMID 34421454

Citations 2

Authors

A O Akinyamoju

O O Gbolahan

B F Adeyemi

Affiliations

Soon will be listed here.

Abstract

Background: Alveolar soft part sarcoma (ASPS) is a rare malignant soft tissue tumour. There is a dearth of literature analyzing its features on the tongue.

Objective: This study aims to conduct a scoping review to describe the essential clinico-pathologic features, treatment modalities and outcome of previously reported tongue ASPS (TASPS) and new cases at our center.

Methods: A search of databases (PubMed, Medline, Cochrane and Google Scholar) and the internet for articles on TASPS written in English was conducted. Information extracted included clinico-pathological and demographic data. Descriptive statistics was used for analysis.

Results: A total of 49 articles were eligible for this study. In all, 81 cases were utilized. Asian studies accounted for most cases 35(43.2%) and a slight female preponderance of 1.1 was seen. Most cases - 38 (46.9%), occurred in the 1 decade and the base of tongue was the most common location in 19 (39.6%) cases. Also, tumour metastasis was present in 14 (25.9%) cases. Transcription Factor E3 (TFE3) - 8 (24.2%) and Neuron Specific Enolase (NSE) - 8 (24.2%) were the most common immunohistochemical stains used and were both expressed 7 out of 8 cases (87.5%). Most common treatment modality was surgery and 42 (82.4%) cases managed by surgery alone were free of disease at ≤ 5 years of follow up.

Conclusion: TASPS slightly affected the female gender and tongue base more commonly. It occurred more in the first two decades of life. Use of standard investigative tools for management will allow for better appraisal of research findings.

Citing Articles

Alveolar Soft Part Sarcoma of the Tongue: A Rare Tumor at an Unusual Location.

Qureshi A, Shalaby A, Al Hasani K, Al-Ajmi E, Qureshi F, Al Badaai Y Cureus. 2023; 15(6):e40647.

PMID: 37476110 PMC: 10355844. DOI: 10.7759/cureus.40647.

Lingual Alveolar Soft Part Sarcoma in a 78-Year-Old Woman: A Case Report and Comprehensive Review of the Literature from 1952 to 2022.

Aksionau A, Dela Cruz N, Meram A, Cuellar-Saenz H, Aveni J, Takei H Head Neck Pathol. 2022; 17(1):265-274.

PMID: 36303014 PMC: 10063713. DOI: 10.1007/s12105-022-01505-x.

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