Use of High-frequency Repetitive Transcranial Magnetic Stimulation to Probe the Neural Circuitry of Food Choice in Anorexia Nervosa: A Proof-of-concept Study

Overview

Journal Int J Eat Disord

Publisher Wiley

Specialty Social Sciences

Date 2021 Aug 20

PMID 34415081

Citations 4

Authors

Alexandra F Muratore

Mariya Bershad

Joanna E Steinglass

Karin E Foerde

Loren Gianini

Allegra Broft

Evelyn Attia

Affiliations

Soon will be listed here.

Abstract

Repetitive transcranial magnetic stimulation (rTMS) is used to modulate neural systems and provides the opportunity for experimental tests of hypotheses regarding mechanisms underlying anorexia nervosa (AN). The present pilot study has investigated whether high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) to a region of the right dorsolateral prefrontal cortex (DLPFC) might be associated with change in food selection among adult inpatients with AN. Ten women received one session of sham and one session of HF-rTMS targeting the right DLPFC while completing a computerized Food Choice Task. Compared to sham, HF-rTMS was associated with changes in food ratings and food choice: inpatients reported higher healthiness ratings of low- and high-fat foods and selected a significantly greater proportion of high-fat foods over a neutrally rated reference item while receiving HF-rTMS. Findings suggest that HF-rTMS to the right DLPFC was associated with a reduction of fat avoidance on a food choice task among inpatients with AN and provide additional support for the possibility that this region, and related neural circuits, may underlie restrictive food choice. Research using rTMS to experimentally test neural mechanisms is needed to elucidate the underpinnings of AN and supports the development of novel treatment targets.

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