Association of Depressive Symptoms with the Progression of Carotid Intima-media Thickness in a Community-based Cohort in Beijing, China

Overview

Journal BMJ Open

Specialty General Medicine

Date 2021 Aug 18

PMID 34404713

Citations 2

Authors

Mengyuan Liu

Jia Jia

Fangfang Fan

Pengfei Sun

Zhongli Wu

Yimeng Jiang

Danmei He

Bo Liu

Ying Yang

Yan Zhang

Affiliations

Soon will be listed here.

Abstract

Objectives: To determine the relationship between depressive symptoms and progression of carotid intima-media thickness (cIMT) in a Beijing community-based population.

Design: Prospective cohort study between 2014 and 2018.

Setting: Dwellers without cardiovascular disease, hypertension or diabetes from a Beijing community.

Participants: 3849 Chinese community-dwelling individuals who underwent baseline screening for depressive symptoms were invited to participate in the study in 2014 and follow-up visit in 2018. Among them, 2124 participants completed carotid ultrasound examination both at baseline and a follow-up visit. After further excluding patients with a history of stroke, myocardial infarction or lower extremity arterial stenosis and those with a diagnosis of hypertension or diabetes and ankle-brachial index ≤0.9 at baseline, 1011 eligible participants were finally included.

Primary Outcome Measure: The rate of mean cIMT change.

Results: Over a median follow-up period of 4.40 years, the overall rate of mean cIMT change was 2.23% (-5.64% to 9.51%). After adjustment for 13 covariates, there was an increase of 2.36% (β=2.36, 95% CI: 0.37 to 4.36, p=0.020) for the rates of mean cIMT change in the depressive group compared with the control group. Furthermore, this association was modified by drinking status (β=3.22, 95% CI: 1.25 to 5.19, P-interaction=0.006).

Conclusion: Depressive symptoms were independently associated with progression of mean cIMT in a community-based cohort in Beijing, China. Furthermore, this relationship was modified by drinking status.

Citing Articles

Association of mental health in childhood, adolescence and young adulthood with cardiovascular risk factors and carotid remodeling below age 30 - results from the KiGGS cohort study.

Buschges J, Beyer A, Schmidt-Trucksass A, Berger K, Neuhauser H Eur J Epidemiol. 2025; 40(1):17-26.

PMID: 39751700 PMC: 11799030. DOI: 10.1007/s10654-024-01189-3.

Association Between Changes in Central Blood Pressure and Peripheral Blood Pressure With New-Onset Hypertension in a Chinese Community-Based Population.

Li K, Fan F, Gao L, Jia J, Jiang Y, Li J J Clin Hypertens (Greenwich). 2024; 26(12):1479-1486.

PMID: 39447025 PMC: 11654846. DOI: 10.1111/jch.14920.

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