Early Life Physical Activity and Risk of Ovarian Cancer in Adulthood

Overview

Journal Int J Cancer

Specialty Oncology

Date 2021 Aug 16

PMID 34398976

Citations 1

Authors

Tianyi Wang

Danielle E Jake-Schoffman

Mary K Townsend

Christine Vinci

Walter C Willett

Shelley S Tworoger

Affiliations

Soon will be listed here.

Abstract

Emerging data suggest that exposures in early life may affect ovarian development and contribute to ovarian cancer risk. We evaluated the association between early life physical activity and risk of ovarian cancer in adulthood in two large prospective cohorts, the Nurses' Health Study (NHS) and NHSII. In total, analyses included 28 232 NHS participants (followed from 2004 to 2016) and 56 553 NHSII participants (followed from 1997 to 2017). Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for risk of ovarian cancer overall and by early life body mass index (BMI). Neither physical activity at ages 12-13, 14-17 or 18-22 years nor average physical activity across these three periods was associated with ovarian cancer risk overall (≥78 vs <24 MET-h/wk, HRs = 1.34, 1.21, 1.08 and 1.24, respectively), or by categories of early life BMI (P ≥ .44). No association was observed with the risk of high-grade serous or poorly differentiated tumors or postmenopausal ovarian cancer. Overall, early life physical activity was not clearly related to ovarian cancer risk during adulthood.

Citing Articles

Physical Activity During Adolescence and Early-adulthood and Ovarian Cancer Among Women with a BRCA1 or BRCA2 Mutation.

Guyonnet E, Kim S, Xia Y, Giannakeas V, Lubinski J, Randall Armel S Cancer Res Commun. 2023; 3(11):2420-2429.

PMID: 38019076 PMC: 10683556. DOI: 10.1158/2767-9764.CRC-23-0223.

References

Wu L, Zheng W, Xiang Y, Gao Y, Li H, Cai H . Physical Activity and Pancreatic Cancer Risk among Urban Chinese: Results from Two Prospective Cohort Studies. Cancer Epidemiol Biomarkers Prev. 2018; 27(4):479-487. PMC: 5971116. DOI: 10.1158/1055-9965.EPI-17-0895. View

Alimujiang A, Imm K, Appleton C, Colditz G, Berkey C, Toriola A . Adiposity at Age 10 and Mammographic Density among Premenopausal Women. Cancer Prev Res (Phila). 2018; 11(5):287-294. PMC: 7473460. DOI: 10.1158/1940-6207.CAPR-17-0309. View

Trabert B, Tworoger S, OBrien K, Townsend M, Fortner R, Iversen E . The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles: An Analysis from the Ovarian Cancer Cohort Consortium (OC3). Cancer Res. 2020; 80(5):1210-1218. PMC: 7056529. DOI: 10.1158/0008-5472.CAN-19-2850. View

Carlson L, Shaw N . Development of Ovulatory Menstrual Cycles in Adolescent Girls. J Pediatr Adolesc Gynecol. 2019; 32(3):249-253. PMC: 6570576. DOI: 10.1016/j.jpag.2019.02.119. View

Weihe P, Spielmann J, Kielstein H, Henning-Klusmann J, Weihrauch-Bluher S . Childhood Obesity and Cancer Risk in Adulthood. Curr Obes Rep. 2020; 9(3):204-212. DOI: 10.1007/s13679-020-00387-w. View

Huang T, Eliassen A, Hankinson S, Okereke O, Kubzansky L, Wang M . A prospective study of leisure-time physical activity and risk of incident epithelial ovarian cancer: Impact by menopausal status. Int J Cancer. 2015; 138(4):843-52. PMC: 4715531. DOI: 10.1002/ijc.29834. View

Gong T, Wu Q, Vogtmann E, Lin B, Wang Y . Age at menarche and risk of ovarian cancer: a meta-analysis of epidemiological studies. Int J Cancer. 2012; 132(12):2894-900. PMC: 3806278. DOI: 10.1002/ijc.27952. View

Katzmarzyk P, Denstel K, Beals K, Carlson J, Crouter S, McKenzie T . Results from the United States 2018 Report Card on Physical Activity for Children and Youth. J Phys Act Health. 2018; 15(S2):S422-S424. DOI: 10.1123/jpah.2018-0476. View

Boeke C, Eliassen A, Oh H, Spiegelman D, Willett W, Tamimi R . Adolescent physical activity in relation to breast cancer risk. Breast Cancer Res Treat. 2014; 145(3):715-24. PMC: 4067160. DOI: 10.1007/s10549-014-2919-5. View

10.

Treloar A, Boynton R, Behn B, BROWN B . Variation of the human menstrual cycle through reproductive life. Int J Fertil. 1970; 12(1 Pt 2):77-126. View

11.

Aarestrup J, Trabert B, Ulrich L, Wentzensen N, Sorensen T, Baker J . Childhood Overweight, Tallness, and Growth Increase Risks of Ovarian Cancer. Cancer Epidemiol Biomarkers Prev. 2018; 28(1):183-188. PMC: 6325003. DOI: 10.1158/1055-9965.EPI-18-0024. View

12.

Schouten L, Rivera C, Hunter D, Spiegelman D, Adami H, Arslan A . Height, body mass index, and ovarian cancer: a pooled analysis of 12 cohort studies. Cancer Epidemiol Biomarkers Prev. 2008; 17(4):902-12. PMC: 2572258. DOI: 10.1158/1055-9965.EPI-07-2524. View

13.

Huang T, Tworoger S, Willett W, Stampfer M, Rosner B . Associations of early life and adulthood adiposity with risk of epithelial ovarian cancer. Ann Oncol. 2018; 30(2):303-309. PMC: 6821311. DOI: 10.1093/annonc/mdy546. View

14.

Friedenreich C, Neilson H, Farris M, Courneya K . Physical Activity and Cancer Outcomes: A Precision Medicine Approach. Clin Cancer Res. 2016; 22(19):4766-4775. DOI: 10.1158/1078-0432.CCR-16-0067. View

15.

Pronk A, Ji B, Shu X, Chow W, Xue S, Yang G . Physical activity and breast cancer risk in Chinese women. Br J Cancer. 2011; 105(9):1443-50. PMC: 3241547. DOI: 10.1038/bjc.2011.370. View

16.

Tworoger S, Eliassen A, Missmer S, Baer H, Rich-Edwards J, Michels K . Birthweight and body size throughout life in relation to sex hormones and prolactin concentrations in premenopausal women. Cancer Epidemiol Biomarkers Prev. 2006; 15(12):2494-501. DOI: 10.1158/1055-9965.EPI-06-0671. View

17.

Rich-Edwards J, Spiegelman D, Garland M, Hertzmark E, Hunter D, Colditz G . Physical activity, body mass index, and ovulatory disorder infertility. Epidemiology. 2002; 13(2):184-90. DOI: 10.1097/00001648-200203000-00013. View

18.

Niehoff N, White A, Sandler D . Childhood and teenage physical activity and breast cancer risk. Breast Cancer Res Treat. 2017; 164(3):697-705. PMC: 5553118. DOI: 10.1007/s10549-017-4276-7. View

19.

Must A, Willett W, Dietz W . Remote recall of childhood height, weight, and body build by elderly subjects. Am J Epidemiol. 1993; 138(1):56-64. DOI: 10.1093/oxfordjournals.aje.a116777. View

20.

Baer H, Schnitt S, Connolly J, Byrne C, Willett W, Rosner B . Early life factors and incidence of proliferative benign breast disease. Cancer Epidemiol Biomarkers Prev. 2005; 14(12):2889-97. DOI: 10.1158/1055-9965.EPI-05-0525. View