NMR Reveals the Interplay Between SilE and SilB Model Peptides in the Context of Silver Resistance

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2021 Aug 16

PMID 34396382

Citations 1

Authors

Lucille Babel

Minh-Ha Nguyen

Cedric Mittelheisser

Marie Martin

Katharina M Fromm

Olivier Walker

Maggy Hologne

Affiliations

Soon will be listed here.

Abstract

SilE and SilB are both proteins involved in the silver efflux pump found in Gram-negative bacteria such as S. typhimurium. Using model peptides along with NMR and CD experiments, we show how SilE may store silver ions prior to delivery and we hypothesize for the first time the interplay between SilB and SilE.

Citing Articles

The battle for silver binding: How the interplay between the SilE, SilF, and SilB proteins contributes to the silver efflux pump mechanism.

Arrault C, Monneau Y, Martin M, Cantrelle F, Boll E, Chirot F J Biol Chem. 2023; 299(8):105004.

PMID: 37394004 PMC: 10407283. DOI: 10.1016/j.jbc.2023.105004.

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