The Evolution of Single-Cell Analysis and Utility in Drug Development

Overview

Journal AAPS J

Specialty Pharmacology

Date 2021 Aug 14

PMID 34389904

Citations 5

Authors

Shibani Mitra-Kaushik

Anita Mehta-Damani

Jennifer J Stewart

Cherie Green

Virginia Litwin

Christele Gonneau

Affiliations

Soon will be listed here.

Abstract

This review provides a brief history of the advances of cellular analysis tools focusing on instrumentation, detection probes, and data analysis tools. The interplay of technological advancement and a deeper understanding of cellular biology are emphasized. The relevance of this topic to drug development is that the evaluation of cellular biomarkers has become a critical component of the development strategy for novel immune therapies, cell therapies, gene therapies, antiviral therapies, and vaccines. Moreover, recent technological advances in single-cell analysis are providing more robust cellular measurements and thus accelerating the advancement of novel therapies.Graphical abstract.

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