Drosophila Satellite Repeats at the Intersection of Chromatin, Gene Regulation and Evolution

Overview

Journal Prog Mol Subcell Biol

Specialties Biochemistry
Molecular Biology

Date 2021 Aug 13

PMID 34386870

Citations 5

Authors

Maggie P Lauria Sneideman

Victoria H Meller

Affiliations

Soon will be listed here.

Abstract

Satellite repeats make up a large fraction of the genomes of many higher eukaryotes. Until recently these sequences were viewed as molecular parasites with few functions. Drosophila melanogaster and related species have a wealth of diverse satellite repeats. Comparative studies of Drosophilids have been instrumental in understanding how these rapidly evolving sequences change and move. Remarkably, satellite repeats have been found to modulate gene expression and mediate genetic conflicts between chromosomes and between closely related fly species. This suggests that satellites play a key role in speciation. We have taken advantage of the depth of research on satellite repeats in flies to review the known functions of these sequences and consider their central role in evolution and gene expression.

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