Human Adenovirus 11 in 2 Renal Transplant Recipients: Suspected Donor-Derived Infection

Overview

Journal Open Forum Infect Dis

Specialty Infectious Diseases

Date 2021 Aug 13

PMID 34386544

Citations 2

Authors

Amy C Sherman

Xiaoyan Lu

Eileen Schneider

Amelia Langston

Carla L Ellis

Stephen Pastan

Julu Bhatnagar

Sarah Reagan-Steiner

Pallavi Annambhotla

Stephen Lindstrom

Aneesh Mehta

Stephanie M Pouch

Marybeth E Sexton

Affiliations

Soon will be listed here.

Abstract

Background: Human adenovirus (HAdV) infections can lead to high mortality in solid organ transplant (SOT) recipients, with rare reports of donor-derived infection.

Methods: Two renal transplant recipients with HAdV-11 infection who received kidneys from the same donor are described. Whole-genome sequencing (WGS) was performed.

Results: WGS showed 100% nucleotide sequence identity for the 2 HAdV-11 isolates. The patients presented with distinct clinical syndromes, and both were treated with brincidofovir.

Conclusions: Donor-derived HAdV infection is presumed to be low; however, disseminated HAdV in SOT recipients can be severe, and clinicians should be aware of the clinical course and treatment options.

Citing Articles

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