CCL2: An Important Mediator Between Tumor Cells and Host Cells in Tumor Microenvironment

Overview

Journal Front Oncol

Specialty Oncology

Date 2021 Aug 13

PMID 34386431

Citations 71

Authors

Jiakang Jin

Jinti Lin

Ankai Xu

Jianan Lou

Chao Qian

Xiumao Li

Yitian Wang

Wei Yu

Huimin Tao

Affiliations

Soon will be listed here.

Abstract

Tumor microenvironment (TME) formation is a major cause of immunosuppression. The TME consists of a considerable number of macrophages and stromal cells that have been identified in multiple tumor types. CCL2 is the strongest chemoattractant involved in macrophage recruitment and a powerful initiator of inflammation. Evidence indicates that CCL2 can attract other host cells in the TME and direct their differentiation in cooperation with other cytokines. Overall, CCL2 has an unfavorable effect on prognosis in tumor patients because of the accumulation of immunosuppressive cell subtypes. However, there is also evidence demonstrating that CCL2 enhances the anti-tumor capability of specific cell types such as inflammatory monocytes and neutrophils. The inflammation state of the tumor seems to have a bi-lateral role in tumor progression. Here, we review works focusing on the interactions between cancer cells and host cells, and on the biological role of CCL2 in these processes.

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