Low-Resolution Neurocognitive Aging and Cognition: An Embodied Perspective

Overview

Journal Front Syst Neurosci

Specialty Neurology

Date 2021 Aug 13

PMID 34385911

Authors

Jordan Mille

Simona M Brambati

Marie Izaute

Guillaume T Vallet

Affiliations

Soon will be listed here.

Abstract

Consistent with embodied cognition, a growing evidence in young adults show that sensorimotor processing is at the core of cognition. Considering that this approach predicts direct interaction between sensorimotor processing and cognition, embodied cognition may thus be particularly relevant to study aging, since this population is characterized by concomitant changes in sensorimotor and cognitive processing. The present perspective aims at showing the value and interest to explore normal aging throughout embodiment by focusing on the neurophysiological and cognitive changes occurring in aging. To this end, we report some of the neurophysiological substrates underpinning the perceptual and memory interactions in older adults, from the low and high perceptual processing to the conjunction in the medial temporal lobe. We then explore how these changes could explain more broadly the cognitive changes associated with aging in terms of losses and gains.

References

Ashendorf L, McCaffrey R . Exploring age-related decline on the Wisconsin Card Sorting Test. Clin Neuropsychol. 2007; 22(2):262-72. DOI: 10.1080/13854040701218436. View

Kent B, Hvoslef-Eide M, Saksida L, Bussey T . The representational-hierarchical view of pattern separation: Not just hippocampus, not just space, not just memory?. Neurobiol Learn Mem. 2016; 129:99-106. DOI: 10.1016/j.nlm.2016.01.006. View

Burke S, Wallace J, Nematollahi S, Uprety A, Barnes C . Pattern separation deficits may contribute to age-associated recognition impairments. Behav Neurosci. 2010; 124(5):559-73. PMC: 3071152. DOI: 10.1037/a0020893. View

McTighe S, Cowell R, Winters B, Bussey T, Saksida L . Paradoxical false memory for objects after brain damage. Science. 2010; 330(6009):1408-10. DOI: 10.1126/science.1194780. View

Marr D . Simple memory: a theory for archicortex. Philos Trans R Soc Lond B Biol Sci. 1971; 262(841):23-81. DOI: 10.1098/rstb.1971.0078. View

Rolls E . The mechanisms for pattern completion and pattern separation in the hippocampus. Front Syst Neurosci. 2013; 7:74. PMC: 3812781. DOI: 10.3389/fnsys.2013.00074. View

Murray , Bussey . Perceptual-mnemonic functions of the perirhinal cortex. Trends Cogn Sci. 1999; 3(4):142-151. DOI: 10.1016/s1364-6613(99)01303-0. View

Graham K, Barense M, Lee A . Going beyond LTM in the MTL: a synthesis of neuropsychological and neuroimaging findings on the role of the medial temporal lobe in memory and perception. Neuropsychologia. 2010; 48(4):831-53. DOI: 10.1016/j.neuropsychologia.2010.01.001. View

Pulvermuller F, Hauk O, Nikulin V, Ilmoniemi R . Functional links between motor and language systems. Eur J Neurosci. 2005; 21(3):793-7. DOI: 10.1111/j.1460-9568.2005.03900.x. View

10.

Boucard C, Hernowo A, Maguire R, Jansonius N, Roerdink J, Hooymans J . Changes in cortical grey matter density associated with long-standing retinal visual field defects. Brain. 2009; 132(Pt 7):1898-906. PMC: 2702836. DOI: 10.1093/brain/awp119. View

11.

Surprenant A, Neath I, Brown G . Modeling age-related differences in immediate memory using SIMPLE. J Mem Lang. 2008; 55(4):572-586. PMC: 2173629. DOI: 10.1016/j.jml.2006.08.001. View

12.

Correia C, Lopez K, Wroblewski K, Huisingh-Scheetz M, Kern D, Chen R . Global Sensory Impairment in Older Adults in the United States. J Am Geriatr Soc. 2016; 64(2):306-313. PMC: 4808743. DOI: 10.1111/jgs.13955. View

13.

de Dieuleveult A, Siemonsma P, van Erp J, Brouwer A . Effects of Aging in Multisensory Integration: A Systematic Review. Front Aging Neurosci. 2017; 9:80. PMC: 5368230. DOI: 10.3389/fnagi.2017.00080. View

14.

Barense M, Gaffan D, Graham K . The human medial temporal lobe processes online representations of complex objects. Neuropsychologia. 2007; 45(13):2963-74. DOI: 10.1016/j.neuropsychologia.2007.05.023. View

15.

Buckley M, Booth M, Rolls E, Gaffan D . Selective perceptual impairments after perirhinal cortex ablation. J Neurosci. 2001; 21(24):9824-36. PMC: 6763048. View

16.

Li S, Lindenberger U, Sikstrom S . Aging cognition: from neuromodulation to representation. Trends Cogn Sci. 2001; 5(11):479-486. DOI: 10.1016/s1364-6613(00)01769-1. View

17.

Leal S, Yassa M . Integrating new findings and examining clinical applications of pattern separation. Nat Neurosci. 2018; 21(2):163-173. PMC: 5898810. DOI: 10.1038/s41593-017-0065-1. View

18.

Yonelinas A . The hippocampus supports high-resolution binding in the service of perception, working memory and long-term memory. Behav Brain Res. 2013; 254:34-44. PMC: 3773061. DOI: 10.1016/j.bbr.2013.05.030. View

19.

Opitz B . Neural binding mechanisms in learning and memory. Neurosci Biobehav Rev. 2009; 34(7):1036-46. DOI: 10.1016/j.neubiorev.2009.11.001. View

20.

Boutet I, Dawod K, Chiasson F, Brown O, Collin C . Perceptual Similarity Can Drive Age-Related Elevation of False Recognition. Front Psychol. 2019; 10:743. PMC: 6520656. DOI: 10.3389/fpsyg.2019.00743. View