Rational Design of Pyrrole Derivatives with Aggregation-induced Phosphorescence Characteristics for Time-resolved and Two-photon Luminescence Imaging

Overview

Journal Nat Commun

Specialty Biology

Date 2021 Aug 13

PMID 34385449

Citations 21

Authors

Jianhui Yang

Yahui Zhang

Xinghui Wu

Wenbo Dai

Dan Chen

Jianbing Shi

Bin Tong

Qian Peng

Haiyan Xie

Zhengxu Cai

Yuping Dong

Xin Zhang

Affiliations

Soon will be listed here.

Abstract

Pure organic room-temperature phosphorescent (RTP) materials have been suggested to be promising bioimaging materials due to their good biocompatibility and long emission lifetime. Herein, we report a class of RTP materials. These materials are developed through the simple introduction of an aromatic carbonyl to a tetraphenylpyrrole molecule and also exhibit aggregation-induced emission (AIE) properties. These molecules show non-emission in solution and purely phosphorescent emission in the aggregated state, which are desirable properties for biological imaging. Highly crystalline nanoparticles can be easily fabricated with a long emission lifetime (20 μs), which eliminate background fluorescence interference from cells and tissues. The prepared nanoparticles demonstrate two-photon absorption characteristics and can be excited by near infrared (NIR) light, making them promising materials for deep-tissue optical imaging. This integrated aggregation-induced phosphorescence (AIP) strategy diversifies the existing pool of bioimaging agents to inspire the development of bioprobes in the future.

Citing Articles

Exploring and Anticipating the Applications of Organic Room-Temperature Phosphorescent Materials in Biomedicine and Dentistry.

Zhang Y, Zhu Y, Deng T, Du Y Int J Nanomedicine. 2024; 19():13201-13216.

PMID: 39670197 PMC: 11636246. DOI: 10.2147/IJN.S492759.

The Bioimaging Story of AIEgens.

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Synergistic -β regulation of porphyrins: squeezing the band gap into the near-infrared I/II region.

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