PERM1 Interacts with the MICOS-MIB Complex to Connect the Mitochondria and Sarcolemma Via Ankyrin B

Overview

Journal Nat Commun

Specialty Biology

Date 2021 Aug 13

PMID 34385433

Citations 6

Authors

Theresa Bock

Clara Turk

Sriram Aravamudhan

Lena Keufgens

Wilhelm Bloch

Dieu Hien Rozsivalova

Vanina Romanello

Leonardo Nogara

Bert Blaauw

Aleksandra Trifunovic

Thomas Braun

Marcus Kruger

Affiliations

Soon will be listed here.

Abstract

Skeletal muscle subsarcolemmal mitochondria (SSM) and intermyofibrillar mitochondria subpopulations have distinct metabolic activity and sensitivity, though the mechanisms that localize SSM to peripheral areas of muscle fibers are poorly understood. A protein interaction study and complexome profiling identifies PERM1 interacts with the MICOS-MIB complex. Ablation of Perm1 in mice reduces muscle force, decreases mitochondrial membrane potential and complex I activity, and reduces the numbers of SSM in skeletal muscle. We demonstrate PERM1 interacts with the intracellular adaptor protein ankyrin B (ANKB) that connects the cytoskeleton to the plasma membrane. Moreover, we identify a C-terminal transmembrane helix that anchors PERM1 into the outer mitochondrial membrane. We conclude PERM1 functions in the MICOS-MIB complex and acts as an adapter to connect the mitochondria with the sarcolemma via ANKB.

Citing Articles

PERM1-An Emerging Transcriptional Regulator of Mitochondrial Biogenesis: A Systematic Review.

Soares Menezes E, Wu Z, Renwick J, Moran-MacDonald A, Gurd B Genes (Basel). 2024; 15(10).

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Cardiac maturation.

Sakamoto T, Kelly D J Mol Cell Cardiol. 2023; 187:38-50.

PMID: 38160640 PMC: 10923079. DOI: 10.1016/j.yjmcc.2023.12.008.

Perm1 Protects the Heart From Pressure Overload-Induced Dysfunction by Promoting Oxidative Metabolism.

Tachibana S, Yu N, Li R, Fernandez-Costa C, Liang A, Choi J Circulation. 2023; 147(11):916-919.

PMID: 36913499 PMC: 10018424. DOI: 10.1161/CIRCULATIONAHA.122.060173.

PERM1 regulates energy metabolism in the heart ERRα/PGC-1α axis.

Oka S, Sreedevi K, Shankar T, Yedla S, Arowa S, James A Front Cardiovasc Med. 2022; 9:1033457.

PMID: 36419485 PMC: 9676655. DOI: 10.3389/fcvm.2022.1033457.

PERM1 regulates genes involved in fatty acid metabolism in the heart by interacting with PPARα and PGC-1α.

Huang C, Oka S, Xu X, Chen C, Tung C, Chang Y Sci Rep. 2022; 12(1):14576.

PMID: 36028747 PMC: 9418182. DOI: 10.1038/s41598-022-18885-3.

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