Interacts with HnRNPM to Inhibit Metastasis by Modulating Alternative Splicing in Gastric Cancer

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2021 Aug 13

PMID 34385309

Citations 69

Authors

Xiaolin Wang

Jingxin Li

Xing Bian

Cheng Wu

Jinghan Hua

Shuhui Chang

Tianyi Yu

Hong Li

Yongxiang Li

Shanshan Hu

Ge Shan

Wenchu Lin

Affiliations

Soon will be listed here.

Abstract

Circular RNAs (circRNAs) have emerged as key regulators of human cancers, yet their modes of action in gastric cancer (GC) remain largely unknown. Here, we identified back-spliced from exons 3 and 4 of unconventional prefoldin RPB5 interactor 1 (URI1) from circRNA profiling of five-paired human gastric and the corresponding nontumor adjacent specimens (paraGC). exhibits the significantly higher expression in GC compared with paraGC and inhibitory effects on cell migration and invasion in vitro and GC metastasis in vivo. Mechanistically, directly interacts with heterogeneous nuclear ribonucleoprotein M (hnRNPM) to modulate alternative splicing of genes, involved in the process of cell migration, thus suppressing GC metastasis. Collectively, our study expands the current knowledge regarding the molecular mechanism of circRNA-mediated cancer metastasis via modulating alternative splicing.

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