-Based Autophagy Activation Reverses Doxorubicin-Induced Cardiotoxicity

Overview

Journal Circ Res

Specialty Cardiology & Vascular Diseases

Date 2021 Aug 13

PMID 34384247

Citations 29

Authors

Yong Wang

Xiaoguang Lu

Xiaoping Wang

Qi Qiu

Ping Zhu

Lin Ma

Xiao Ma

Joerg Herrmann

Xueying Lin

Wei Wang

Xiaolei Xu

Affiliations

Soon will be listed here.

Abstract

[Figure: see text].

Citing Articles

Histidine triad nucleotide-binding protein 2 attenuates doxorubicin-induced cardiotoxicity through restoring lysosomal function and promoting autophagy in mice.

Jiang H, Zhang J, Jia D, Liu L, Gao J, Zhang B MedComm (2020). 2025; 6(3):e70075.

PMID: 39968501 PMC: 11831189. DOI: 10.1002/mco2.70075.

Knockdown gene by rAAV9 alleviates doxorubicin-induced cardiac toxicity by inhibiting GATA4 autophagic degradation.

Xu A, Shen Z, Wang S, Luan H, Xu Y, Kang Z Front Pharmacol. 2025; 15:1496380.

PMID: 39931517 PMC: 11808915. DOI: 10.3389/fphar.2024.1496380.

The transcriptional repressor HEY2 regulates mitochondrial oxidative respiration to maintain cardiac homeostasis.

She P, Gao B, Li D, Wu C, Zhu X, He Y Nat Commun. 2025; 16(1):232.

PMID: 39747914 PMC: 11696871. DOI: 10.1038/s41467-024-55557-4.

Decoration of Autophagy Detecting Nanoparticle with an Anionic Fluorochrome Enhances Multispectral Characterization of Autophagosome Location and Flux.

Akam-Baxter E, Chen H, Boukhalfa A, Yu A, Ling L, Kung A Small. 2024; 21(6):e2407915.

PMID: 39723734 PMC: 11821426. DOI: 10.1002/smll.202407915.

Porphyromonas gingivalis inducing autophagy-related biological dysfunction in alveolar epithelial cells: an in vitro study.

Zhao Q, Wang X, Liu W, Tian H, Yang H, Wang Z BMC Oral Health. 2024; 24(1):1478.

PMID: 39639253 PMC: 11619664. DOI: 10.1186/s12903-024-05253-y.

References

Wang X, Wang Q, Li W, Zhang Q, Jiang Y, Guo D . TFEB-NF-κB inflammatory signaling axis: a novel therapeutic pathway of Dihydrotanshinone I in doxorubicin-induced cardiotoxicity. J Exp Clin Cancer Res. 2020; 39(1):93. PMC: 7245789. DOI: 10.1186/s13046-020-01595-x. View

Dutta D, Dutta D, Xu J, Dirain M, Leeuwenburgh C . Calorie restriction combined with resveratrol induces autophagy and protects 26-month-old rat hearts from doxorubicin-induced toxicity. Free Radic Biol Med. 2014; 74:252-62. PMC: 4146714. DOI: 10.1016/j.freeradbiomed.2014.06.011. View

Zon L, Peterson R . In vivo drug discovery in the zebrafish. Nat Rev Drug Discov. 2005; 4(1):35-44. DOI: 10.1038/nrd1606. View

Turner P, Brabb T, Pekow C, Vasbinder M . Administration of substances to laboratory animals: routes of administration and factors to consider. J Am Assoc Lab Anim Sci. 2012; 50(5):600-13. PMC: 3189662. View

Kawaguchi T, Takemura G, Kanamori H, Takeyama T, Watanabe T, Morishita K . Prior starvation mitigates acute doxorubicin cardiotoxicity through restoration of autophagy in affected cardiomyocytes. Cardiovasc Res. 2012; 96(3):456-65. DOI: 10.1093/cvr/cvs282. View

Shin J, Pomerantsev E, Mably J, MacRae C . High-resolution cardiovascular function confirms functional orthology of myocardial contractility pathways in zebrafish. Physiol Genomics. 2010; 42(2):300-9. PMC: 3032279. DOI: 10.1152/physiolgenomics.00206.2009. View

Yu X, Ruan Y, Huang X, Dou L, Lan M, Cui J . Dexrazoxane ameliorates doxorubicin-induced cardiotoxicity by inhibiting both apoptosis and necroptosis in cardiomyocytes. Biochem Biophys Res Commun. 2019; 523(1):140-146. DOI: 10.1016/j.bbrc.2019.12.027. View

Collymore C, Rasmussen S, Tolwani R . Gavaging adult zebrafish. J Vis Exp. 2013; (78). PMC: 3855001. DOI: 10.3791/50691. View

Sciarretta S, Maejima Y, Zablocki D, Sadoshima J . The Role of Autophagy in the Heart. Annu Rev Physiol. 2017; 80:1-26. DOI: 10.1146/annurev-physiol-021317-121427. View

10.

Wang X, Li C, Wang Q, Li W, Guo D, Zhang X . Tanshinone IIA Restores Dynamic Balance of Autophagosome/Autolysosome in Doxorubicin-Induced Cardiotoxicity via Targeting Beclin1/LAMP1. Cancers (Basel). 2019; 11(7). PMC: 6679133. DOI: 10.3390/cancers11070910. View

11.

Levine B, Packer M, Codogno P . Development of autophagy inducers in clinical medicine. J Clin Invest. 2015; 125(1):14-24. PMC: 4382267. DOI: 10.1172/JCI73938. View

12.

Herrmann J . Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia. Nat Rev Cardiol. 2020; 17(8):474-502. PMC: 8782611. DOI: 10.1038/s41569-020-0348-1. View

13.

Robertson A, Holmes G, Bojarczuk A, Burgon J, Loynes C, Chimen M . A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism. Sci Transl Med. 2014; 6(225):225ra29. PMC: 4247228. DOI: 10.1126/scitranslmed.3007672. View

14.

Matias M, Silvestre S, Falcao A, Alves G . Considerations and Pitfalls in Selecting the Drug Vehicles for Evaluation of New Drug Candidates: Focus on in vivo Pharmaco-Toxicological Assays Based on the Rotarod Performance Test. J Pharm Pharm Sci. 2018; 21(1):110-118. DOI: 10.18433/jpps29656. View

15.

Bartlett J, Trivedi P, Yeung P, Kienesberger P, Pulinilkunnil T . Doxorubicin impairs cardiomyocyte viability by suppressing transcription factor EB expression and disrupting autophagy. Biochem J. 2016; 473(21):3769-3789. DOI: 10.1042/BCJ20160385. View

16.

Vejpongsa P, Yeh E . Prevention of anthracycline-induced cardiotoxicity: challenges and opportunities. J Am Coll Cardiol. 2014; 64(9):938-45. DOI: 10.1016/j.jacc.2014.06.1167. View

17.

Zhang S, Liu X, Bawa-Khalfe T, Lu L, Lyu Y, Liu L . Identification of the molecular basis of doxorubicin-induced cardiotoxicity. Nat Med. 2012; 18(11):1639-42. DOI: 10.1038/nm.2919. View

18.

Ding Y, Sun X, Huang W, Hoage T, Redfield M, Kushwaha S . Haploinsufficiency of target of rapamycin attenuates cardiomyopathies in adult zebrafish. Circ Res. 2011; 109(6):658-69. PMC: 3166359. DOI: 10.1161/CIRCRESAHA.111.248260. View

19.

Pinzon-Olejua A, Welte C, Chekuru A, Bosak V, Brand M, Hans S . Cre-inducible site-specific recombination in zebrafish oligodendrocytes. Dev Dyn. 2016; 246(1):41-49. DOI: 10.1002/dvdy.24458. View

20.

Zilinyi R, Czompa A, Czegledi A, Gajtko A, Pituk D, Lekli I . The Cardioprotective Effect of Metformin in Doxorubicin-Induced Cardiotoxicity: The Role of Autophagy. Molecules. 2018; 23(5). PMC: 6100061. DOI: 10.3390/molecules23051184. View