Inhibitory Effect of Kaempferol on Mouse Melanoma Cell Line B16 and

Overview

Journal Postepy Dermatol Alergol

Publisher Termedia

Specialty Allergy & Immunology

Date 2021 Aug 11

PMID 34377134

Citations 8

Authors

Di Qiang

Cao Ci

Wenbei Liu

Jun Wang

Caifeng He

Bihua Ji

Xuefei Shao

Affiliations

Soon will be listed here.

Abstract

Introduction: Melanoma is a malignant tumour and is the leading cause of death in patients with skin tumours.

Aim: Kaempferol belongs to a class of flavonoids, and is associated with many biological functions such as anti-inflammatory, anti-oxidation and anti-cancer. However, the inhibitory effect of kaempferol on melanoma still remains unclear.

Material And Methods: The effect of kaempferol on melanoma was determined by conducting both and experiments using MTT assay and flow cytometry.

Results: The results revealed that kaempferol obviously inhibited cell viability of melanoma B16 cells, induced cell cycle arrest and cell apoptosis. The results showed that kaempferol effectively inhibited the growth of mice xenografts. More importantly, kaempferol down-regulated the number of MDSC cells and up-regulated the number of NKT cells and CD8 T cells in the spleen.

Conclusions: Taken together, these findings indicate that kaempferol might play an inhibitory role in the growth of melanoma by enhancing anti-tumour immunity of organisms.

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