Choice-relevant Information Transformation Along a Ventrodorsal Axis in the Medial Prefrontal Cortex

Overview

Journal Nat Commun

Specialty Biology

Date 2021 Aug 11

PMID 34376663

Citations 19

Authors

David J-N Maisson

Tyler V Cash-Padgett

Maya Z Wang

Benjamin Y Hayden

Sarah R Heilbronner

Jan Zimmermann

Affiliations

Soon will be listed here.

Abstract

Choice-relevant brain regions in prefrontal cortex may progressively transform information about options into choices. Here, we examine responses of neurons in four regions of the medial prefrontal cortex as macaques performed two-option risky choices. All four regions encode economic variables in similar proportions and show similar putative signatures of key choice-related computations. We provide evidence to support a gradient of function that proceeds from areas 14 to 25 to 32 to 24. Specifically, we show that decodability of twelve distinct task variables increases along that path, consistent with the idea that regions that are higher in the anatomical hierarchy make choice-relevant variables more separable. We also show progressively longer intrinsic timescales in the same series. Together these results highlight the importance of the medial wall in choice, endorse a specific gradient-based organization, and argue against a modular functional neuroanatomy of choice.

Citing Articles

Rational inattention in neural coding for economic choice.

Fine J, Moreno-Bote R, Hayden B bioRxiv. 2024; .

PMID: 39386501 PMC: 11463532. DOI: 10.1101/2024.09.20.614193.

Gaze-centered gating, reactivation, and reevaluation of economic value in orbitofrontal cortex.

Ferro D, Cash-Padgett T, Wang M, Hayden B, Moreno-Bote R Nat Commun. 2024; 15(1):6163.

PMID: 39039055 PMC: 11263430. DOI: 10.1038/s41467-024-50214-2.

Neural timescales reflect behavioral demands in freely moving rhesus macaques.

Manea A, Maisson D, Voloh B, Zilverstand A, Hayden B, Zimmermann J Nat Commun. 2024; 15(1):2151.

PMID: 38461167 PMC: 10925022. DOI: 10.1038/s41467-024-46488-1.

Cortical timescales and the modular organization of structural and functional brain networks.

Lurie D, Pappas I, DEsposito M Hum Brain Mapp. 2024; 45(2):e26587.

PMID: 38339903 PMC: 10823764. DOI: 10.1002/hbm.26587.

Dorsal raphe neurons signal integrated value during multi-attribute decision-making.

Feng Y, Bromberg-Martin E, Monosov I bioRxiv. 2023; .

PMID: 37662243 PMC: 10473596. DOI: 10.1101/2023.08.17.553745.

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