Immunity and Viral Infections: Modulating Antiviral Response Via CRISPR-Cas Systems

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2021 Aug 10

PMID 34372578

Citations 6

Authors

Sergey Brezgin

Anastasiya Kostyusheva

Ekaterina Bayurova

Elena Volchkova

Vladimir Gegechkori

Ilya Gordeychuk

Dieter Glebe

Dmitry Kostyushev

Vladimir Chulanov

Affiliations

Soon will be listed here.

Abstract

Viral infections cause a variety of acute and chronic human diseases, sometimes resulting in small local outbreaks, or in some cases spreading across the globe and leading to global pandemics. Understanding and exploiting virus-host interactions is instrumental for identifying host factors involved in viral replication, developing effective antiviral agents, and mitigating the severity of virus-borne infectious diseases. The diversity of CRISPR systems and CRISPR-based tools enables the specific modulation of innate immune responses and has contributed impressively to the fields of virology and immunology in a very short time. In this review, we describe the most recent advances in the use of CRISPR systems for basic and translational studies of virus-host interactions.

Citing Articles

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Molecular Function of cGAS-STING in SARS-CoV-2: A Novel Approach to COVID-19 Treatment.

Moossavi M, Rastegar M, Moossavi S, Khorasani M Biomed Res Int. 2022; 2022:6189254.

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Signaling Induced by Chronic Viral Hepatitis: Dependence and Consequences.

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The Regulatory Network of Cyclic GMP-AMP Synthase-Stimulator of Interferon Genes Pathway in Viral Evasion.

Hu T, Pan M, Yin Y, Wang C, Cui Y, Wang Q Front Microbiol. 2021; 12:790714.

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