Mesenchymal Stem Cells and Tuberculosis: Clinical Challenges and Opportunities

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2021 Aug 9

PMID 34367155

Citations 8

Authors

Xueying Zhang

Qi Xie

Ziyu Ye

Yanyun Li

Zhengping Che

Mingyuan Huang

Jincheng Zeng

Affiliations

Soon will be listed here.

Abstract

Tuberculosis (TB) is one of the communicable diseases caused by (Mtb) infection, affecting nearly one-third of the world's population. However, because the pathogenesis of TB is still not fully understood and the development of anti-TB drug is slow, TB remains a global public health problem. In recent years, with the gradual discovery and confirmation of the immunomodulatory properties of mesenchymal stem cells (MSCs), more and more studies, including our team's research, have shown that MSCs seem to be closely related to the growth status of Mtb and the occurrence and development of TB, which is expected to bring new hope for the clinical treatment of TB. This article reviews the relationship between MSCs and the occurrence and development of TB and the potential application of MSCs in the treatment of TB.

Citing Articles

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Human mesenchymal stromal cells inhibit replication in clinically relevant models of lung infection.

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