The Molecular Mechanism of Sex Hormones on Sertoli Cell Development and Proliferation

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2021 Aug 9

PMID 34367061

Citations 21

Authors

Wasim Shah

Ranjha Khan

Basit Shah

Asad Khan

Sobia Dil

Wei Liu

Jie Wen

Xiaohua Jiang

Affiliations

Soon will be listed here.

Abstract

Sustaining and maintaining the intricate process of spermatogenesis is liable upon hormones and growth factors acting through endocrine and paracrine pathways. The Sertoli cells (SCs) are the major somatic cells present in the seminiferous tubules and are considered to be the main regulators of spermatogenesis. As each Sertoli cell supports a specific number of germ cells, thus, the final number of Sertoli cells determines the sperm production capacity. Similarly, sex hormones are also major regulators of spermatogenesis and they can determine the proliferation of Sertoli cells. In the present review, we have critically and comprehensively discussed the role of sex hormones and some other factors that are involved in Sertoli cell proliferation, differentiation and maturation. Furthermore, we have also presented a model of Sertoli cell development based upon the recent advancement in the field of reproduction. Hence, our review article provides a general overview regarding the sex hormonal pathways governing Sertoli cell proliferation and development.

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References

Jiang X, Bukhari I, Zheng W, Yin S, Wang Z, Cooke H . Blood-testis barrier and spermatogenesis: lessons from genetically-modified mice. Asian J Androl. 2014; 16(4):572-80. PMC: 4104086. DOI: 10.4103/1008-682X.125401. View

Levallet G, Bonnamy P, Levallet J . Alteration of cell membrane proteoglycans impairs FSH receptor/Gs coupling and ERK activation through PP2A-dependent mechanisms in immature rat Sertoli cells. Biochim Biophys Acta. 2013; 1830(6):3466-75. DOI: 10.1016/j.bbagen.2013.02.027. View

Martins A, Alves M, Simoes V, Dias T, Rato L, Moreira P . Control of Sertoli cell metabolism by sex steroid hormones is mediated through modulation in glycolysis-related transporters and enzymes. Cell Tissue Res. 2013; 354(3):861-8. DOI: 10.1007/s00441-013-1722-7. View

Ben Maamar M, Lesne L, Hennig K, Desdoits-Lethimonier C, Kilcoyne K, Coiffec I . Ibuprofen results in alterations of human fetal testis development. Sci Rep. 2017; 7:44184. PMC: 5345102. DOI: 10.1038/srep44184. View

Dschietzig T, Bartsch C, Baumann G, Stangl K . Relaxin-a pleiotropic hormone and its emerging role for experimental and clinical therapeutics. Pharmacol Ther. 2006; 112(1):38-56. DOI: 10.1016/j.pharmthera.2006.03.004. View

Gilleron J, Nebout M, Scarabelli L, Senegas-Balas F, Palmero S, Segretain D . A potential novel mechanism involving connexin 43 gap junction for control of sertoli cell proliferation by thyroid hormones. J Cell Physiol. 2006; 209(1):153-61. DOI: 10.1002/jcp.20716. View

Bhattacharya I, Basu S, Pradhan B, Sarkar H, Nagarajan P, Majumdar S . Testosterone augments FSH signaling by upregulating the expression and activity of FSH-Receptor in Pubertal Primate Sertoli cells. Mol Cell Endocrinol. 2018; 482:70-80. DOI: 10.1016/j.mce.2018.12.012. View

McDonald C, Millena A, Reddy S, Finlay S, Vizcarra J, Khan S . Follicle-stimulating hormone-induced aromatase in immature rat Sertoli cells requires an active phosphatidylinositol 3-kinase pathway and is inhibited via the mitogen-activated protein kinase signaling pathway. Mol Endocrinol. 2005; 20(3):608-18. DOI: 10.1210/me.2005-0245. View

Johnston H, Baker P, Abel M, Charlton H, Jackson G, Fleming L . Regulation of Sertoli cell number and activity by follicle-stimulating hormone and androgen during postnatal development in the mouse. Endocrinology. 2003; 145(1):318-29. DOI: 10.1210/en.2003-1055. View

10.

Syed V, Khan S, Lindh M, Ritzen E . Ontogeny and cellular origin of a rat seminiferous tubule factor(s) that inhibits LH-dependent testosterone production by interstitial cells in vitro. Int J Androl. 1987; 10(5):711-20. DOI: 10.1111/j.1365-2605.1987.tb00373.x. View

11.

Bois C, Delalande C, Nurmio M, Parvinen M, Zanatta L, Toppari J . Age- and cell-related gene expression of aromatase and estrogen receptors in the rat testis. J Mol Endocrinol. 2010; 45(3):147-59. DOI: 10.1677/JME-10-0041. View

12.

Ma Y, Wang H . PI3K/Akt/FoxO: a novel participant in signal transduction in bone cells under mechanical stimulation. Cell Biol Int. 2012; 36(10):923-6. DOI: 10.1042/CBI20120078. View

13.

Meroni S, Riera M, Pellizzari E, Cigorraga S . Regulation of rat Sertoli cell function by FSH: possible role of phosphatidylinositol 3-kinase/protein kinase B pathway. J Endocrinol. 2002; 174(2):195-204. DOI: 10.1677/joe.0.1740195. View

14.

Orth J, Higginbotham C, Salisbury R . Hemicastration causes and testosterone prevents enhanced uptake of [3H] thymidine by Sertoli cells in testes of immature rats. Biol Reprod. 1984; 30(1):263-70. DOI: 10.1095/biolreprod30.1.263. View

15.

Hazra R, Corcoran L, Robson M, McTavish K, Upton D, Handelsman D . Temporal role of Sertoli cell androgen receptor expression in spermatogenic development. Mol Endocrinol. 2012; 27(1):12-24. PMC: 5416944. DOI: 10.1210/me.2012-1219. View

16.

Kerr G, Young J, Horvay K, Abud H, Loveland K . Regulated Wnt/beta-catenin signaling sustains adult spermatogenesis in mice. Biol Reprod. 2013; 90(1):3. DOI: 10.1095/biolreprod.112.105809. View

17.

Ulloa-Aguirre A, Reiter E, Crepieux P . FSH Receptor Signaling: Complexity of Interactions and Signal Diversity. Endocrinology. 2018; 159(8):3020-3035. DOI: 10.1210/en.2018-00452. View

18.

Galdieri M, Monaco L, Stefanini M . Secretion of androgen binding protein by Sertoli cells is influenced by contact with germ cells. J Androl. 1984; 5(6):409-15. DOI: 10.1002/j.1939-4640.1984.tb00806.x. View

19.

Rother K, Accili D . Role of insulin receptors and IGF receptors in growth and development. Pediatr Nephrol. 2000; 14(7):558-61. DOI: 10.1007/s004670000351. View

20.

Makela J, Koskenniemi J, Virtanen H, Toppari J . Testis Development. Endocr Rev. 2018; 40(4):857-905. DOI: 10.1210/er.2018-00140. View