Omega-3 Index and Clinical Outcomes of Severe COVID-19: Preliminary Results of a Cross-Sectional Study

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2021 Aug 7

PMID 34360016

Citations 16

Authors

Rodrigo Zapata B

Jose Miguel Muller

Juan Enrique Vasquez

Franco Ravera

Gustavo Lago

Eduardo Canon

Daniella Castaneda

Madelaine Pradenas

Muriel Ramirez-Santana

Affiliations

Soon will be listed here.

Abstract

The potentially detrimental effects of the worldwide deficiency of Omega-3 fatty acids on the COVID-19 pandemic have been underestimated. The Omega-3 Index (O3I), clinical variables, biometric indices, and nutritional information were directly determined for 74 patients with severe COVID-19 and 10 healthy quality-control subjects. The relationships between the OI3 and mechanical ventilation (MV) and death were analyzed. Results: Patients with COVID-19 exhibited low O3I (mean: 4.15%; range: 3.06-6.14%)-consistent with insufficient fish and Omega-3 supplement consumption, and markedly lower than the healthy control subjects (mean: 7.84%; range: 4.65-10.71%). Inverse associations were observed between O3I and MV (OR = 0.459; C.I.: 0.211-0.997) and death (OR = 0.28; C.I.: 0.08-0.985) in severe COVID-19, even after adjusting for sex, age, and well-known risk factors. Conclusion: We present preliminary evidence to support the hypothesis that the risk of severe COVID-19 can be stratified by the O3I quartile. Further investigations are needed to assess the value of the O3I as a blood marker for COVID-19.

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References

Thuppal S, von Schacky C, Harris W, Sherif K, Denby N, Steinbaum S . Discrepancy between Knowledge and Perceptions of Dietary Omega-3 Fatty Acid Intake Compared with the Omega-3 Index. Nutrients. 2017; 9(9). PMC: 5622690. DOI: 10.3390/nu9090930. View

Arnardottir H, Pawelzik S, Ohlund Wistbacka U, Artiach G, Hofmann R, Reinholdsson I . Stimulating the Resolution of Inflammation Through Omega-3 Polyunsaturated Fatty Acids in COVID-19: Rationale for the Trial. Front Physiol. 2021; 11:624657. PMC: 7830247. DOI: 10.3389/fphys.2020.624657. View

Leuti A, Maccarrone M, Chiurchiu V . Proresolving Lipid Mediators: Endogenous Modulators of Oxidative Stress. Oxid Med Cell Longev. 2019; 2019:8107265. PMC: 6604337. DOI: 10.1155/2019/8107265. View

ODriscoll M, Ribeiro Dos Santos G, Wang L, Cummings D, Azman A, Paireau J . Age-specific mortality and immunity patterns of SARS-CoV-2. Nature. 2020; 590(7844):140-145. DOI: 10.1038/s41586-020-2918-0. View

Block R, Harris W, Pottala J . Determinants of Blood Cell Omega-3 Fatty Acid Content. Open Biomark J. 2009; 1:1-6. PMC: 2785093. DOI: 10.2174/1875318300801010001. View

Jain A, Aggarwal K, Zhang P . Omega-3 fatty acids and cardiovascular disease. Eur Rev Med Pharmacol Sci. 2015; 19(3):441-5. View

Jackson K, Polreis J, Tintle N, Kris-Etherton P, Harris W . Association of reported fish intake and supplementation status with the omega-3 index. Prostaglandins Leukot Essent Fatty Acids. 2019; 142:4-10. DOI: 10.1016/j.plefa.2019.01.002. View

Back M, Hansson G . Omega-3 fatty acids, cardiovascular risk, and the resolution of inflammation. FASEB J. 2019; 33(2):1536-1539. DOI: 10.1096/fj.201802445R. View

Fritsche K . The science of fatty acids and inflammation. Adv Nutr. 2015; 6(3):293S-301S. PMC: 4424767. DOI: 10.3945/an.114.006940. View

10.

Schwarz B, Sharma L, Roberts L, Peng X, Bermejo S, Leighton I . Cutting Edge: Severe SARS-CoV-2 Infection in Humans Is Defined by a Shift in the Serum Lipidome, Resulting in Dysregulation of Eicosanoid Immune Mediators. J Immunol. 2020; 206(2):329-334. PMC: 7962598. DOI: 10.4049/jimmunol.2001025. View

11.

Larrieu T, Laye S . Food for Mood: Relevance of Nutritional Omega-3 Fatty Acids for Depression and Anxiety. Front Physiol. 2018; 9:1047. PMC: 6087749. DOI: 10.3389/fphys.2018.01047. View

12.

Krishnamoorthy N, Abdulnour R, Walker K, Engstrom B, Levy B . Specialized Proresolving Mediators in Innate and Adaptive Immune Responses in Airway Diseases. Physiol Rev. 2018; 98(3):1335-1370. PMC: 6168922. DOI: 10.1152/physrev.00026.2017. View

13.

Tay M, Poh C, Renia L, Macary P, Ng L . The trinity of COVID-19: immunity, inflammation and intervention. Nat Rev Immunol. 2020; 20(6):363-374. PMC: 7187672. DOI: 10.1038/s41577-020-0311-8. View

14.

Walker R, Jackson K, Tintle N, Shearer G, Bernasconi A, Masson S . Predicting the effects of supplemental EPA and DHA on the omega-3 index. Am J Clin Nutr. 2019; 110(4):1034-1040. DOI: 10.1093/ajcn/nqz161. View

15.

Zhang X, Tan Y, Ling Y, Lu G, Liu F, Yi Z . Viral and host factors related to the clinical outcome of COVID-19. Nature. 2020; 583(7816):437-440. DOI: 10.1038/s41586-020-2355-0. View

16.

Serhan C . Pro-resolving lipid mediators are leads for resolution physiology. Nature. 2014; 510(7503):92-101. PMC: 4263681. DOI: 10.1038/nature13479. View

17.

Serhan C, Chiang N, Dalli J . The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution. Semin Immunol. 2015; 27(3):200-15. PMC: 4515371. DOI: 10.1016/j.smim.2015.03.004. View

18.

Bhardwaj S, Passi S, Misra A, Pant K, Anwar K, Pandey R . Effect of heating/reheating of fats/oils, as used by Asian Indians, on trans fatty acid formation. Food Chem. 2016; 212:663-70. DOI: 10.1016/j.foodchem.2016.06.021. View

19.

Michalakis K, Ilias I . SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects. Diabetes Metab Syndr. 2020; 14(4):469-471. PMC: 7189186. DOI: 10.1016/j.dsx.2020.04.033. View

20.

Calder P . Omega-3 fatty acids and inflammatory processes: from molecules to man. Biochem Soc Trans. 2017; 45(5):1105-1115. DOI: 10.1042/BST20160474. View