Epithelial Protein Lost in Neoplasm, EPLIN, the Cellular and Molecular Prospects in Cancers

Overview

Journal Biomolecules

Publisher MDPI

Specialties Biochemistry
Molecular Biology

Date 2021 Aug 6

PMID 34356662

Citations 11

Authors

Jianyuan Zeng

Wen G Jiang

Andrew J Sanders

Affiliations

Soon will be listed here.

Abstract

Epithelial Protein Lost In Neoplasm (EPLIN), also known as LIMA1 (LIM Domain And Actin Binding 1), was first discovered as a protein differentially expressed in normal and cancerous cell lines. It is now known to be key to the progression and metastasis of certain solid tumours. Despite a slow pace in understanding the biological role in cells and body systems, as well as its clinical implications in the early years since its discovery, recent years have witnessed a rapid progress in understanding the mechanisms of this protein in cells, diseases and indeed the body. EPLIN has drawn more attention over the past few years with its roles expanding from cell migration and cytoskeletal dynamics, to cell cycle, gene regulation, angiogenesis/lymphangiogenesis and lipid metabolism. This concise review summarises and discusses the recent progress in understanding EPLIN in biological processes and its implications in cancer.

Citing Articles

An antagonistic role of clock genes and lima1 in kidney regeneration.

He X, Wang Z, Cheng L, Wang H, Sun Y Commun Biol. 2025; 8(1):29.

PMID: 39789202 PMC: 11718004. DOI: 10.1038/s42003-025-07455-8.

Identification and validation of M2 macrophage-related gene signature as a novel prognostic model for head and neck squamous cell carcinoma.

He S, Chen H, Li C, Feng B, Zhang R, Zhao H Sci Rep. 2024; 14(1):25338.

PMID: 39455885 PMC: 11512021. DOI: 10.1038/s41598-024-76866-0.

Expression and molecular insights of lima1 in cholangiocarcinoma.

Obulkasim H, Adili A, Liu Y, Duan S Cell Adh Migr. 2024; 18(1):4-17.

PMID: 39076043 PMC: 11290767. DOI: 10.1080/19336918.2024.2383068.

Lipotoxic hepatocyte derived LIMA1 enriched small extracellular vesicles promote hepatic stellate cells activation via inhibiting mitophagy.

Li S, Yang F, Cheng F, Zhu L, Yan Y Cell Mol Biol Lett. 2024; 29(1):82.

PMID: 38822260 PMC: 11140962. DOI: 10.1186/s11658-024-00596-4.

Integrative analysis reveals associations between oral microbiota dysbiosis and host genetic and epigenetic aberrations in oral cavity squamous cell carcinoma.

Cai L, Zhu H, Mou Q, Wong P, Lan L, Ng C NPJ Biofilms Microbiomes. 2024; 10(1):39.

PMID: 38589501 PMC: 11001959. DOI: 10.1038/s41522-024-00511-x.

References

Zhang S, Wang X, Iqbal S, Wang Y, Osunkoya A, Chen Z . Epidermal growth factor promotes protein degradation of epithelial protein lost in neoplasm (EPLIN), a putative metastasis suppressor, during epithelial-mesenchymal transition. J Biol Chem. 2012; 288(3):1469-79. PMC: 3548460. DOI: 10.1074/jbc.M112.438341. View

Zhang Y, Fu Z, Wei J, Qi W, Baituola G, Luo J . A variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption. Science. 2018; 360(6393):1087-1092. DOI: 10.1126/science.aao6575. View

Liu R, Martin T, Jordan N, Ruge F, Ye L, Jiang W . Epithelial protein lost in neoplasm-α (EPLIN-α) is a potential prognostic marker for the progression of epithelial ovarian cancer. Int J Oncol. 2016; 48(6):2488-96. DOI: 10.3892/ijo.2016.3462. View

Tsurumi H, Harita Y, Kurihara H, Kosako H, Hayashi K, Matsunaga A . Epithelial protein lost in neoplasm modulates platelet-derived growth factor-mediated adhesion and motility of mesangial cells. Kidney Int. 2014; 86(3):548-57. DOI: 10.1038/ki.2014.85. View

Han M, Kosako H, Watanabe T, Hattori S . Extracellular signal-regulated kinase/mitogen-activated protein kinase regulates actin organization and cell motility by phosphorylating the actin cross-linking protein EPLIN. Mol Cell Biol. 2007; 27(23):8190-204. PMC: 2169166. DOI: 10.1128/MCB.00661-07. View

Dart D, Koushyar S, Lanning B, Jiang W . MiR-221 Is Specifically Elevated in PC3 Cells and its Deletion Reduces Adhesion, Motility and Growth. Anticancer Res. 2019; 39(10):5311-5327. DOI: 10.21873/anticanres.13724. View

Zhang S, Wang X, Osunkoya A, Iqbal S, Wang Y, Muller S . EPLIN downregulation promotes epithelial-mesenchymal transition in prostate cancer cells and correlates with clinical lymph node metastasis. Oncogene. 2011; 30(50):4941-52. PMC: 3165108. DOI: 10.1038/onc.2011.199. View

Pretzsch E, Bosch F, Neumann J, Ganschow P, Bazhin A, Guba M . Mechanisms of Metastasis in Colorectal Cancer and Metastatic Organotropism: Hematogenous versus Peritoneal Spread. J Oncol. 2019; 2019:7407190. PMC: 6770301. DOI: 10.1155/2019/7407190. View

Goncalves J, Sharma A, Coyaud E, Laurent E, Raught B, Pelletier L . LUZP1 and the tumor suppressor EPLIN modulate actin stability to restrict primary cilia formation. J Cell Biol. 2020; 219(7). PMC: 7337498. DOI: 10.1083/jcb.201908132. View

10.

Song Y, Maul R, Sachi Gerbin C, Chang D . Inhibition of anchorage-independent growth of transformed NIH3T3 cells by epithelial protein lost in neoplasm (EPLIN) requires localization of EPLIN to actin cytoskeleton. Mol Biol Cell. 2002; 13(4):1408-16. PMC: 102278. DOI: 10.1091/mbc.01-08-0414. View

11.

Li X, Zhou J, Chen Z, Chng W . P53 mutations in colorectal cancer - molecular pathogenesis and pharmacological reactivation. World J Gastroenterol. 2015; 21(1):84-93. PMC: 4284363. DOI: 10.3748/wjg.v21.i1.84. View

12.

Zhitnyak I, Rubtsova S, Litovka N, Gloushankova N . Early Events in Actin Cytoskeleton Dynamics and E-Cadherin-Mediated Cell-Cell Adhesion during Epithelial-Mesenchymal Transition. Cells. 2020; 9(3). PMC: 7140442. DOI: 10.3390/cells9030578. View

13.

Chang D, Park N, Denny C, Nelson S, Pe M . Characterization of transformation related genes in oral cancer cells. Oncogene. 1998; 16(15):1921-30. DOI: 10.1038/sj.onc.1201715. View

14.

Saitoh S, Maruyama T, Yako Y, Kajita M, Fujioka Y, Ohba Y . Rab5-regulated endocytosis plays a crucial role in apical extrusion of transformed cells. Proc Natl Acad Sci U S A. 2017; 114(12):E2327-E2336. PMC: 5373379. DOI: 10.1073/pnas.1602349114. View

15.

Sundvold H, Sundvold-Gjerstad V, Malerod-Fjeld H, Haglund K, Stenmark H, Malerod L . Arv1 promotes cell division by recruiting IQGAP1 and myosin to the cleavage furrow. Cell Cycle. 2016; 15(5):628-43. PMC: 4845929. DOI: 10.1080/15384101.2016.1146834. View

16.

Taha M, Aldirawi M, Marz S, Seebach J, Odenthal-Schnittler M, Bondareva O . EPLIN-α and -β Isoforms Modulate Endothelial Cell Dynamics through a Spatiotemporally Differentiated Interaction with Actin. Cell Rep. 2019; 29(4):1010-1026.e6. DOI: 10.1016/j.celrep.2019.09.043. View

17.

Chen N, Uddin B, Hardt R, Ding W, Panic M, Lucibello I . Human phosphatase CDC14A regulates actin organization through dephosphorylation of epithelial protein lost in neoplasm. Proc Natl Acad Sci U S A. 2017; 114(20):5201-5206. PMC: 5441781. DOI: 10.1073/pnas.1619356114. View

18.

Sanders A, Martin T, Ye L, Mason M, Jiang W . EPLIN is a negative regulator of prostate cancer growth and invasion. J Urol. 2011; 186(1):295-301. DOI: 10.1016/j.juro.2011.03.038. View

19.

Steder M, Alla V, Meier C, Spitschak A, Pahnke J, Furst K . DNp73 exerts function in metastasis initiation by disconnecting the inhibitory role of EPLIN on IGF1R-AKT/STAT3 signaling. Cancer Cell. 2013; 24(4):512-27. DOI: 10.1016/j.ccr.2013.08.023. View

20.

Collins R, Jiang W, Hargest R, Mason M, Sanders A . EPLIN: a fundamental actin regulator in cancer metastasis?. Cancer Metastasis Rev. 2015; 34(4):753-64. PMC: 4661189. DOI: 10.1007/s10555-015-9595-8. View