Behind the Scene: Exploiting MC1R in Skin Cancer Risk and Prevention

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2021 Aug 6

PMID 34356109

Citations 13

Authors

Michele Manganelli

Stefania Guida

Anna Ferretta

Giovanni Pellacani

Letizia Porcelli

Amalia Azzariti

Gabriella Guida

Affiliations

Soon will be listed here.

Abstract

Melanoma and non-melanoma skin cancers (NMSCs) are the most frequent cancers of the skin in white populations. An increased risk in the development of skin cancers has been associated with the combination of several environmental factors (i.e., ultraviolet exposure) and genetic background, including melanocortin-1 receptor () status. In the last few years, advances in the diagnosis of skin cancers provided a great impact on clinical practice. Despite these advances, NMSCs are still the most common malignancy in humans and melanoma still shows a rising incidence and a poor prognosis when diagnosed at an advanced stage. Efforts are required to underlie the genetic and clinical heterogeneity of melanoma and NMSCs, leading to an optimization of the management of affected patients. The clinical implications of the impact of germline variants in melanoma and NMSCs' risk, together with the additional risk conferred by somatic mutations in other peculiar genes, as well as the role of screening in skin cancers' prevention will be addressed in the current review.

Citing Articles

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A Side-by-Side Comparison of Wildtype and Variant Melanocortin 1 Receptor Signaling with Emphasis on Protection against Oxidative Damage to DNA.

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