A Sensitive Method for the Detection of Legacy and Emerging Per- and Polyfluorinated Alkyl Substances (PFAS) in Dairy Milk

Overview

Journal Anal Bioanal Chem

Specialty Chemistry

Date 2021 Aug 6

PMID 34355253

Citations 4

Authors

Nicholas I Hill

Jitka Becanova

Rainer Lohmann

Affiliations

Soon will be listed here.

Abstract

There is widespread contamination by per- and polyfluoroalkyl substances (PFAS) across the globe, with adverse effects on human and environmental health. For human exposure, drinking water and dietary exposure have been recognized as important PFAS exposure pathway for the general population. Several documented cases of dairy milk contamination by PFAS have raised concerns over this exposure pathway in general. A sensitive method for determination of 27 PFAS in milk was hence modified and applied on raw and processed milk samples from 13 farms across the United States (U.S.). A combination of acid and basic extraction method and ENVI-Carb clean-up achieved recoveries of targeted PFAS between 70 and 141%. The method detection limits (MDL) ranged from 0.8 to 22 ng/L (for 26 PFAS) and 144 ng/L for perfluorobutanoic acid (PFBA). The uniqueness of this method is considered in the targeted screening of a broad range of legacy PFAS, as well as perfluorinated sulfonamide species and fluorotelomer sulfonates. No legacy PFAS were detected in 13 milk samples from regions of concern given local use of biosolids or proximity to fire training areas. Overall, then, the uptake of perfluoroalkyl acids (PFAA) from dairy milk in the U.S. is considered low.

Citing Articles

There's Something in What We Eat: An Overview on the Extraction Techniques and Chromatographic Analysis for PFAS Identification in Agri-Food Products.

Iannone A, Carriera F, Passarella S, Fratianni A, Avino P Foods. 2024; 13(7).

PMID: 38611389 PMC: 11011820. DOI: 10.3390/foods13071085.

Recent Advances in the Chromatographic Analysis of Emerging Pollutants in Dairy Milk: A Review (2018-2023).

Ashraf D, Morsi R, Usman M, Meetani M Molecules. 2024; 29(6).

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An Overview on Recent Advances in Biomimetic Sensors for the Detection of Perfluoroalkyl Substances.

Ahmadi Tabar F, Lowdon J, Bakhshi Sichani S, Khorshid M, Cleij T, Dilien H Sensors (Basel). 2024; 24(1).

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Integrated QuEChERS combined with LC-MS/MS for high-throughput analysis of per- and polyfluoroalkyl substances in milk.

Shi R, Liu L, Liu X, Liu Z, Liu J, Wang J Anal Bioanal Chem. 2023; 416(1):203-214.

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References

Blaine A, Rich C, Hundal L, Lau C, Mills M, Harris K . Uptake of perfluoroalkyl acids into edible crops via land applied biosolids: field and greenhouse studies. Environ Sci Technol. 2013; 47(24):14062-9. DOI: 10.1021/es403094q. View

Coggan T, Moodie D, Kolobaric A, Szabo D, Shimeta J, Crosbie N . An investigation into per- and polyfluoroalkyl substances (PFAS) in nineteen Australian wastewater treatment plants (WWTPs). Heliyon. 2019; 5(8):e02316. PMC: 6716228. DOI: 10.1016/j.heliyon.2019.e02316. View

Chen W, Bai F, Chang Y, Chen P, Chen C . Concentrations of perfluoroalkyl substances in foods and the dietary exposure among Taiwan general population and pregnant women. J Food Drug Anal. 2018; 26(3):994-1004. PMC: 9303023. DOI: 10.1016/j.jfda.2017.12.011. View

Nickerson A, Rodowa A, Adamson D, Field J, Kulkarni P, Kornuc J . Spatial Trends of Anionic, Zwitterionic, and Cationic PFASs at an AFFF-Impacted Site. Environ Sci Technol. 2020; 55(1):313-323. DOI: 10.1021/acs.est.0c04473. View

Schultz M, Barofsky D, Field J . Quantitative determination of fluorotelomer sulfonates in groundwater by LC MS/MS. Environ Sci Technol. 2004; 38(6):1828-35. DOI: 10.1021/es035031j. View

Hu X, Andrews D, Lindstrom A, Bruton T, Schaider L, Grandjean P . Detection of Poly- and Perfluoroalkyl Substances (PFASs) in U.S. Drinking Water Linked to Industrial Sites, Military Fire Training Areas, and Wastewater Treatment Plants. Environ Sci Technol Lett. 2016; 3(10):344-350. PMC: 5062567. DOI: 10.1021/acs.estlett.6b00260. View

Kowalczyk J, Ehlers S, Oberhausen A, Tischer M, Furst P, Schafft H . Absorption, distribution, and milk secretion of the perfluoroalkyl acids PFBS, PFHxS, PFOS, and PFOA by dairy cows fed naturally contaminated feed. J Agric Food Chem. 2013; 61(12):2903-12. DOI: 10.1021/jf304680j. View

Capriotti A, Cavaliere C, Cavazzini A, Foglia P, Lagana A, Piovesana S . High performance liquid chromatography tandem mass spectrometry determination of perfluorinated acids in cow milk. J Chromatogr A. 2013; 1319:72-9. DOI: 10.1016/j.chroma.2013.10.029. View

Filipovic M, Berger U . Are perfluoroalkyl acids in waste water treatment plant effluents the result of primary emissions from the technosphere or of environmental recirculation?. Chemosphere. 2014; 129:74-80. DOI: 10.1016/j.chemosphere.2014.07.082. View

10.

Keller J, Calafat A, Kato K, Ellefson M, Reagen W, Strynar M . Determination of perfluorinated alkyl acid concentrations in human serum and milk standard reference materials. Anal Bioanal Chem. 2009; 397(2):439-51. DOI: 10.1007/s00216-009-3222-x. View

11.

Xing Z, Lu J, Liu Z, Li S, Wang G, Wang X . Occurrence of Perfluorooctanoic Acid and Perfluorooctane Sulfonate in Milk and Yogurt and Their Risk Assessment. Int J Environ Res Public Health. 2016; 13(10). PMC: 5086776. DOI: 10.3390/ijerph13101037. View

12.

Clarke B, Smith S . Review of 'emerging' organic contaminants in biosolids and assessment of international research priorities for the agricultural use of biosolids. Environ Int. 2010; 37(1):226-47. DOI: 10.1016/j.envint.2010.06.004. View

13.

Berendsen B, Lakraoui F, Leenders L, van Leeuwen S . The analysis of perfluoroalkyl substances at ppt level in milk and egg using UHPLC-MS/MS. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2020; 37(10):1707-1718. DOI: 10.1080/19440049.2020.1794053. View

14.

Tittlemier S, Braekevelt E . Analysis of polyfluorinated compounds in foods. Anal Bioanal Chem. 2010; 399(1):221-7. DOI: 10.1007/s00216-010-4112-y. View

15.

Becanova J, Saleeba Z, Stone A, Robuck A, Hurt R, Lohmann R . A graphene-based hydrogel monolith with tailored surface chemistry for PFAS passive sampling. Environ Sci Nano. 2022; 8(10):2894-2907. PMC: 8963211. DOI: 10.1039/d1en00517k. View

16.

Kowalczyk J, Ehlers S, Furst P, Schafft H, Lahrssen-Wiederholt M . Transfer of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) from contaminated feed into milk and meat of sheep: pilot study. Arch Environ Contam Toxicol. 2012; 63(2):288-98. DOI: 10.1007/s00244-012-9759-2. View

17.

Alder A, van der Voet J . Occurrence and point source characterization of perfluoroalkyl acids in sewage sludge. Chemosphere. 2014; 129:62-73. DOI: 10.1016/j.chemosphere.2014.07.045. View

18.

Weber A, Barber L, LeBlanc D, Sunderland E, Vecitis C . Geochemical and Hydrologic Factors Controlling Subsurface Transport of Poly- and Perfluoroalkyl Substances, Cape Cod, Massachusetts. Environ Sci Technol. 2017; 51(8):4269-4279. DOI: 10.1021/acs.est.6b05573. View

19.

Houtz E, Higgins C, Field J, Sedlak D . Persistence of perfluoroalkyl acid precursors in AFFF-impacted groundwater and soil. Environ Sci Technol. 2013; 47(15):8187-95. DOI: 10.1021/es4018877. View

20.

Barbarossa A, Gazzotti T, Zironi E, Serraino A, Pagliuca G . Short communication: Monitoring the presence of perfluoroalkyl substances in Italian cow milk. J Dairy Sci. 2014; 97(6):3339-43. DOI: 10.3168/jds.2014-8005. View