Genome-wide Association Study of Trypanosome Prevalence and Morphometric Traits in Purebred and Crossbred Baoulé Cattle of Burkina Faso

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2021 Aug 5

PMID 34351956

Citations 3

Authors

Bernadette Yougbare

Albert Soudre

Dominique Ouedraogo

Bienvenue L Zoma

Arnaud S R Tapsoba

Moumouni Sanou

Salifou Ouedraogo-Kone

Pamela A Burger

Maria Wurzinger

Negar Khayatzadeh

Hamidou H Tamboura

Okeyo Ally Mwai

Amadou Traore

Johann Solkner

Gabor Meszaros

Affiliations

Soon will be listed here.

Abstract

In this study, single-SNP GWAS analyses were conducted to find regions affecting tolerance against trypanosomosis and morphometrics traits in purebred and crossbred Baoulé cattle of Burkina Faso. The trypanosomosis status (positive and negative) and a wide set of morphological traits were recorded for purebred Baoulé and crossbred Zebu x Baoulé cattle, and genotyped with the Illumina Bovine SNP50 BeadChip. After quality control, 36,203 SNPs and 619 animals including 343 purebred Baoulé and 279 crossbreds were used for the GWAS analyses. Several important genes were found that can influence morphological parameters. Although there were no genes identified with a reported strong connection to size traits, many of them were previously identified in various growth-related studies. A re-occurring theme for the genes residing in the regions identified by the most significant SNPs was pleiotropic effect on growth of the body and the cardiovascular system. Regarding trypanosomosis tolerance, two potentially important regions were identified in purebred Baoulé on chromosomes 16 and 24, containing the CFH, CRBN, TRNT1 and, IL5RA genes, and one additional genomic region in Baoulé, x Zebu crossbreds on chromosome 5, containing MGAT4C and NTS. Almost all of these regions and genes were previously related to the trait of interest, while the CRBN gene was to our knowledge presented in the context of trypanosomiasis tolerance for the first time.

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References

Heid H, Werner E, Franke W . The complement of native alpha-keratin polypeptides of hair-forming cells: a subset of eight polypeptides that differ from epithelial cytokeratins. Differentiation. 1986; 32(2):101-19. DOI: 10.1111/j.1432-0436.1986.tb00562.x. View

Taye M, Lee W, Caetano-Anolles K, Dessie T, Hanotte O, Mwai O . Whole genome detection of signature of positive selection in African cattle reveals selection for thermotolerance. Anim Sci J. 2017; 88(12):1889-1901. DOI: 10.1111/asj.12851. View

Jain J, Jain S, Walker L, Tekwani B . Inhibitors of ubiquitin E3 ligase as potential new antimalarial drug leads. BMC Pharmacol Toxicol. 2017; 18(1):40. PMC: 5457628. DOI: 10.1186/s40360-017-0147-4. View

Zhou X, Stephens M . Genome-wide efficient mixed-model analysis for association studies. Nat Genet. 2012; 44(7):821-4. PMC: 3386377. DOI: 10.1038/ng.2310. View

Li Y, Gao Y, Kim Y, Iqbal A, Kim J . A whole genome association study to detect additive and dominant single nucleotide polymorphisms for growth and carcass traits in Korean native cattle, Hanwoo. Asian-Australas J Anim Sci. 2016; 30(1):8-19. PMC: 5205596. DOI: 10.5713/ajas.16.0170. View

Kennedy A, Schmidt C, Thompson J, Weiss G, Taechalertpaisarn T, Gilson P . Recruitment of Factor H as a Novel Complement Evasion Strategy for Blood-Stage Plasmodium falciparum Infection. J Immunol. 2015; 196(3):1239-48. DOI: 10.4049/jimmunol.1501581. View

Han B, Yuan Y, Shi L, Li Y, Liu L, Sun D . Identification of single nucleotide polymorphisms of and genes and their genetic associations with milk production traits in dairy cows. J Anim Sci Biotechnol. 2019; 10:81. PMC: 6833155. DOI: 10.1186/s40104-019-0392-z. View

Juszczuk-Kubiak E, Wicinska K, Starzynski R . Postnatal expression patterns and polymorphism analysis of the bovine myocyte enhancer factor 2C (Mef2C) gene. Meat Sci. 2014; 98(4):753-8. DOI: 10.1016/j.meatsci.2014.06.015. View

Tiberti N, Hainard A, Lejon V, Robin X, Ngoyi D, Turck N . Discovery and verification of osteopontin and Beta-2-microglobulin as promising markers for staging human African trypanosomiasis. Mol Cell Proteomics. 2010; 9(12):2783-95. PMC: 3101862. DOI: 10.1074/mcp.M110.001008. View

10.

Xu Z, Gong J, Maiti D, Vong L, Wu L, Schwarz J . MEF2C ablation in endothelial cells reduces retinal vessel loss and suppresses pathologic retinal neovascularization in oxygen-induced retinopathy. Am J Pathol. 2012; 180(6):2548-60. PMC: 3378855. DOI: 10.1016/j.ajpath.2012.02.021. View

11.

Wood A, Esko T, Yang J, Vedantam S, Pers T, Gustafsson S . Defining the role of common variation in the genomic and biological architecture of adult human height. Nat Genet. 2014; 46(11):1173-86. PMC: 4250049. DOI: 10.1038/ng.3097. View

12.

Kim S, Ka S, Ha J, Kim J, Yoo D, Kim K . Cattle genome-wide analysis reveals genetic signatures in trypanotolerant N'Dama. BMC Genomics. 2017; 18(1):371. PMC: 5427609. DOI: 10.1186/s12864-017-3742-2. View

13.

Hou L, Xu J, Jiao Y, Li H, Pan Z, Duan J . MiR-27b Promotes Muscle Development by Inhibiting MDFI Expression. Cell Physiol Biochem. 2018; 46(6):2271-2283. DOI: 10.1159/000489595. View

14.

Garcia D, Russo-Maenza A, Miceli D, Valdecantos P, Roldan-Olarte M . The urokinase plasminogen activator system components are regulated by vascular endothelial growth factor D in bovine oviduct. Zygote. 2018; 26(3):242-249. DOI: 10.1017/S0967199418000151. View

15.

Doyle J, Berry D, Veerkamp R, Carthy T, Evans R, Walsh S . Genomic regions associated with muscularity in beef cattle differ in five contrasting cattle breeds. Genet Sel Evol. 2020; 52(1):2. PMC: 6993462. DOI: 10.1186/s12711-020-0523-1. View

16.

Mudadu M, Porto-Neto L, Mokry F, Tizioto P, Oliveira P, Tullio R . Genomic structure and marker-derived gene networks for growth and meat quality traits of Brazilian Nelore beef cattle. BMC Genomics. 2016; 17:235. PMC: 4791965. DOI: 10.1186/s12864-016-2535-3. View

17.

McGowan K, Coulombe P . The wound repair-associated keratins 6, 16, and 17. Insights into the role of intermediate filaments in specifying keratinocyte cytoarchitecture. Subcell Biochem. 1999; 31:173-204. View

18.

Chang C, Chow C, Tellier L, Vattikuti S, Purcell S, Lee J . Second-generation PLINK: rising to the challenge of larger and richer datasets. Gigascience. 2015; 4:7. PMC: 4342193. DOI: 10.1186/s13742-015-0047-8. View

19.

Fitzsimons C, Kenny D, Waters S, Earley B, McGee M . Effects of phenotypic residual feed intake on response to a glucose tolerance test and gene expression in the insulin signaling pathway in longissimus dorsi in beef cattle. J Anim Sci. 2014; 92(10):4616-31. DOI: 10.2527/jas.2014-7699. View

20.

Villarreal-Ramos B, Berg S, Whelan A, Holbert S, Carreras F, Salguero F . Experimental infection of cattle with Mycobacterium tuberculosis isolates shows the attenuation of the human tubercle bacillus for cattle. Sci Rep. 2018; 8(1):894. PMC: 5772528. DOI: 10.1038/s41598-017-18575-5. View