[Nonaretritic Central Retinal Artery Occlusion As Marker for the Generalized Vascular Risk]

Overview

Journal Ophthalmologe

Specialty Ophthalmology

Date 2021 Aug 5

PMID 34350493

Authors

Nicolas Feltgen

Jan Liman

Maximilian Schultheiss

Martin S Spitzer

Amelie Pielen

Sven Poli

Affiliations

Soon will be listed here.

Abstract

Background: Retinal artery occlusion (RAO) represents a limiting visual perception for affected patients. In all efforts to improve function it must not be forgotten that in the vast majority of cases the cause is one or more severe vascular or cardiac diseases, which can cause RAO just as ischemic stroke and can also be life-threatening.

Objective: The aim of this article is to present the available literature and to explain the importance of an intensive neurological internal medical clarification in RAO patients.

Conclusion: Although cardiovascular diseases are already known in most patients at the onset of an RAO, further risk factors are detected in almost 80% of cases. Therefore, and because of the high risk for recurrent thromboembolism, immediate and standardized neurological internal medical clarification of the cause is urgently recommended after an acute RAO in the context of an inpatient stay.

References

Avery M, Magal I, Kherani A, Mitha A . Risk of Stroke in Patients With Ocular Arterial Occlusive Disorders: A Retrospective Canadian Study. J Am Heart Assoc. 2019; 8(3):e010509. PMC: 6405587. DOI: 10.1161/JAHA.118.010509. View

Biousse V, Nahab F, Newman N . Management of Acute Retinal Ischemia: Follow the Guidelines!. Ophthalmology. 2018; 125(10):1597-1607. DOI: 10.1016/j.ophtha.2018.03.054. View

Brown G, Magargal L . Central retinal artery obstruction and visual acuity. Ophthalmology. 1982; 89(1):14-9. DOI: 10.1016/s0161-6420(82)34853-8. View

Callizo J, Feltgen N, Ammermann A, Ganser J, Bemme S, Bertelmann T . Atrial fibrillation in retinal vascular occlusion disease and non-arteritic anterior ischemic optic neuropathy. PLoS One. 2017; 12(8):e0181766. PMC: 5542383. DOI: 10.1371/journal.pone.0181766. View

Callizo J, Feltgen N, Pantenburg S, Wolf A, Neubauer A, Jurklies B . Cardiovascular Risk Factors in Central Retinal Artery Occlusion: Results of a Prospective and Standardized Medical Examination. Ophthalmology. 2015; 122(9):1881-8. DOI: 10.1016/j.ophtha.2015.05.044. View

Chang Y, Chu C, Weng S, Chang C, Wang J, Jan R . The risk of acute coronary syndrome after retinal artery occlusion: a population-based cohort study. Br J Ophthalmol. 2014; 99(2):227-31. DOI: 10.1136/bjophthalmol-2014-305451. View

Chang Y, Jan R, Weng S, Wang J, Chio C, Wei F . Retinal artery occlusion and the 3-year risk of stroke in Taiwan: a nationwide population-based study. Am J Ophthalmol. 2012; 154(4):645-652.e1. DOI: 10.1016/j.ajo.2012.03.046. View

Chodnicki K, Pulido J, Hodge D, Klaas J, Chen J . Stroke Risk Before and After Central Retinal Artery Occlusion in a US Cohort. Mayo Clin Proc. 2019; 94(2):236-241. DOI: 10.1016/j.mayocp.2018.10.018. View

Christiansen C, Torp-Pedersen C, Olesen J, Gislason G, Lamberts M, Carlson N . Risk of incident atrial fibrillation in patients presenting with retinal artery or vein occlusion: a nationwide cohort study. BMC Cardiovasc Disord. 2018; 18(1):91. PMC: 5944106. DOI: 10.1186/s12872-018-0825-1. View

10.

French D, Margo C, Greenberg P . Ischemic Stroke Risk in Medicare Beneficiaries with Central Retinal Artery Occlusion: A Retrospective Cohort Study. Ophthalmol Ther. 2018; 7(1):125-131. PMC: 5997602. DOI: 10.1007/s40123-018-0126-x. View

11.

Hayreh S . Central retinal artery occlusion. Indian J Ophthalmol. 2018; 66(12):1684-1694. PMC: 6256872. DOI: 10.4103/ijo.IJO_1446_18. View

12.

Hayreh S, Podhajsky P, Zimmerman M . Retinal artery occlusion: associated systemic and ophthalmic abnormalities. Ophthalmology. 2009; 116(10):1928-36. PMC: 2757505. DOI: 10.1016/j.ophtha.2009.03.006. View

13.

Hong J, Sohn S, Kwak J, Yoo J, Ahn S, Woo S . Retinal artery occlusion and associated recurrent vascular risk with underlying etiologies. PLoS One. 2017; 12(6):e0177663. PMC: 5453434. DOI: 10.1371/journal.pone.0177663. View

14.

Kang E, Lin Y, Wang N, Yeung L, Luo C, Wu W . Aspirin use in central retinal arterial occlusion to prevent ischaemic stroke: a retrospective cohort study in Taiwan. BMJ Open. 2019; 9(2):e025455. PMC: 6398622. DOI: 10.1136/bmjopen-2018-025455. View

15.

Laczynski D, Gallop J, Lyden S, Bena J, Yuan A, Smolock C . Retinal artery occlusion does not portend an increased risk of stroke. J Vasc Surg. 2019; 72(1):198-203. DOI: 10.1016/j.jvs.2019.08.279. View

16.

Lang G, Spraul C . [Risk factors for retinal occlusive diseases]. Klin Monbl Augenheilkd. 1998; 211(4):217-26. DOI: 10.1055/s-2008-1035126. View

17.

Lavin P, Patrylo M, Hollar M, Espaillat K, Kirshner H, Schrag M . Stroke Risk and Risk Factors in Patients With Central Retinal Artery Occlusion. Am J Ophthalmol. 2018; 196:96-100. DOI: 10.1016/j.ajo.2018.08.027. View

18.

Lavin P, Patrylo M, Hollar M, Espaillat K, Kirshner H, Schrag M . Stroke Risk and Risk Factors in Patients With Central Retinal Artery Occlusion. Am J Ophthalmol. 2019; 200:271-272. DOI: 10.1016/j.ajo.2019.01.021. View

19.

Lee K, Tschoe C, Coffman S, Kittel C, Brown P, Vu Q . Management of Acute Central Retinal Artery Occlusion, a "Retinal Stroke": An Institutional Series and Literature Review. J Stroke Cerebrovasc Dis. 2020; 30(2):105531. DOI: 10.1016/j.jstrokecerebrovasdis.2020.105531. View

20.

Leisser C, Kaufmann T, Feltgen N, Schumacher M, Schmoor C, Meckel S . Distribution of internal carotid artery plaque locations among patients with central retinal artery occlusion in the Eagle study population. Graefes Arch Clin Exp Ophthalmol. 2014; 253(8):1227-30. DOI: 10.1007/s00417-014-2804-2. View