A Novel Mechanism of Cannabidiol in Suppressing Hepatocellular Carcinoma by Inducing GSDME Dependent Pyroptosis

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2021 Aug 5

PMID 34350183

Citations 37

Authors

Fugen Shangguan

Hongfei Zhou

Nengfang Ma

Shanshan Wu

Huimin Huang

Guihua Jin

Shijia Wu

Weilong Hong

Weiwei Zhuang

Hongping Xia

Linhua Lan

Affiliations

Soon will be listed here.

Abstract

Cannabidiol (CBD), a phytochemical derived from L., has been demonstrated to exhibit promising anti-tumor properties in multiple cancer types. However, the effects of CBD on hepatocellular carcinoma (HCC) cells remain unknown. We have shown that CBD effectively suppresses HCC cell growth and , and induced HCC cell pyroptosis in a caspase-3/GSDME-dependent manner. We further demonstrated that accumulation of integrative stress response (ISR) and mitochondrial stress may contribute to the initiation of pyroptotic signaling by CBD. Simultaneously, CBD can repress aerobic glycolysis through modulation of the ATF4-IGFBP1-Akt axis, due to the depletion of ATP and crucial intermediate metabolites. Collectively, these observations indicate that CBD could be considered as a potential compound for HCC therapy.

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