Desmopressin Nasal Spray Reduces Blood Loss and Improves the Quality of the Surgical Field During Functional Endoscopic Sinus Surgery

Overview

Journal J Anaesthesiol Clin Pharmacol

Specialty Anesthesiology

Date 2021 Aug 5

PMID 34349377

Citations 5

Authors

Reza Safaeian

Valiollah Hassani

Arman Ghandi

Masood Mohseni

Affiliations

Soon will be listed here.

Abstract

Background And Aims: Making a dry surgical field during functional endoscopic sinus surgery (FESS) is a challenge for anesthetists. This study was conducted to evaluate the pre-emptive hemostatic effects of a single dose of an intranasal spray of desmopressin (DDAVP) in sinus surgery.

Material And Methods: Sixty consecutive patient's as first-time candidates for FESS due to chronic sinusitis were enrolled. They were randomly allocated to receive either a nasal spray of DDAVP 20 μg or sterile water before induction of anesthesia. Management of anesthesia was achieved with propofol and remifentanil infusions. Blood loss, quality of the surgical field, and surgeon's satisfaction were compared between the two groups.

Results: Blood loss in the DDAVP group was 147 ± 43 mL and in the placebo group 212 ± 64 mL (mean ± SD, < 0.01). The quality of the surgical field in the DDAVP group was better than the placebo group. (median score, 1 (1-2) vs. 2 (1-3), = 0.017). Surgeons were more satisfied with the surgical field in the DDAVP group than in the control group (median score, 4 (2.8-5) vs. 3 (2-3), = 0.04).

Conclusion: Premedication with nasal spray DDAVP 20 μg effectively reduces bleeding and improves the surgical field during FESS.

Citing Articles

Does Desmopressin Reduce Intraoperative Bleeding in Patients Who Undergo Nasal Surgery? A Systematic Review and Meta-Analysis.

Kim S, Bae A, Kim D, Hwang S J Rhinol. 2024; 31(1):8-16.

PMID: 39664036 PMC: 11566543. DOI: 10.18787/jr.2024.00007.

Potential clinical applications of current and future oral forms of desmopressin (Review).

Everaert K, Holm-Larsen T, Bou Kheir G, Rottey S, Weiss J, Walle J Exp Ther Med. 2024; 28(2):303.

PMID: 38873038 PMC: 11170333. DOI: 10.3892/etm.2024.12592.

Investigation of the effects of intranasal desmopressin on the bleeding of the patients during open septorhinoplasty: A randomized double-blind clinical trial.

Akbarpour M, Jalali M, Akbari M, Nasirmohtaram S, Haddadi S, Faghih Habibi A Heliyon. 2023; 9(7):e17855.

PMID: 37455992 PMC: 10344754. DOI: 10.1016/j.heliyon.2023.e17855.

Effect of desmopressin on bleeding during endoscopic sinus surgery: A randomized clinical trial.

Akbarpour M, Jalali M, Akbari M, Haddadi S, Fani G Laryngoscope Investig Otolaryngol. 2022; 7(4):920-927.

PMID: 36000037 PMC: 9392372. DOI: 10.1002/lio2.841.

Comments on published article "Desmopressin nasal spray reduces blood loss and improves the quality of the surgical field during functional endoscopic sinus surgery".

Singh A, Anand R, Ray B J Anaesthesiol Clin Pharmacol. 2021; 37(3):493.

PMID: 34759573 PMC: 8562449. DOI: 10.4103/joacp.joacp_365_21.

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