MiR-3187-3p Enhances Migration and Invasion by Targeting PER2 in Head and Neck Squamous Cell Carcinomas

Overview

Journal J Cancer

Specialty Oncology

Date 2021 Aug 2

PMID 34335939

Citations 5

Authors

Lei Xiao

Chao Liu

Shuiting Zhang

Yuanzheng Qiu

Donghai Huang

Diekuo Zhang

Huihong Chen

Hang Ling

Yong Liu

Xin Zhang

Affiliations

Soon will be listed here.

Abstract

Invasion and metastasis are major contributors to treatment failure in patients with head and neck squamous cell carcinomas (HNSCCs) and microRNAs (miRNAs) are reported to play important roles in tumor progression. Our study therefore try to find the crucial miRNAs and reveal their molecular and functional mechanisms involved in migration and invasion of HNSCCs. Through The Cancer Genome Atlas (TCGA) data analysis, we screened out miR-3187-3p and its biological function and specific mechanism were further analyzed. The wound-healing and transwell invasion assay demonstrated that miR-3187-3p promoted the capacity of migration and invasion of HNSCCs . Luciferase reporter assays showed that PER2 was a direct target of miR-3187-3p, which could reverse the effect of miR-3187-3p in HNSCCs. Furthermore, we found that miR-3187-3p / PER2 axis activated the Wnt / β-catenin signaling pathway in HNSCCs. Altogether, our study indicated that miR-3187-3p enhanced migration and invasion by targeting PER2 in HNSCCs.

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