A Romanian Study on the Impact of Glypressin in Laparoscopic Myomectomy

Overview

Journal Exp Ther Med

Specialty Pathology

Date 2021 Aug 2

PMID 34335897

Citations 1

Authors

Daniela Roxana Matasariu

Alexandra Ursache

Loredana Himiniuc

Bogdan Toma

Vasile Lucian Boiculese

Dorina Rudisteanu

Irina Dumitrascu

Affiliations

Soon will be listed here.

Abstract

A major myomectomy-associated problem is excessive blood loss. The aim of the present study was to evaluate the effect of glypressin on blood loss during laparoscopic myomectomy (LM) in women with uterine myomas. A total of 188 women scheduled for LM for uterine myomas were divided into two groups. The one group of women (n=64) received a 5-ml intramyometrial injection of glypressin 0.2 mg/ml (glypressin group; group 1). The other group of women (n=124) (group 2) had an LM performed without any other method to reduce blood loss. The decrease in postoperative hemoglobin (Hb), hematocrit (Ht), morbidity and duration of hospital stay were assessed. The results revealed that Hb and Ht (as it was presumed) exhibited similar changes in our study. Statistically significant differences (P<0.05) were obtained between the two groups in terms of Hb and Ht; after LM both Hb and Ht were decreased. In conclusion, the impact of glypressin administration in hemorrhage control in uterine leiomyomas may establish new future perspectives, regarding its administration in gynecological hemorrhagic pathologies.

Citing Articles

A systematic review and meta-analysis of efficacy of vasopressin as a vasoconstrictive and uterotonic drug in laparoscopic myomectomy.

Balachandran A, Mishra R, Effie A, Raghunathan A, Mathew A, Archana S J Minim Access Surg. 2024; 20(4):363-372.

PMID: 39724600 PMC: 11601973. DOI: 10.4103/jmas.jmas_272_23.

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