Effect of Yiqi Huoxue Granules on Platelet Activation Induced by Thrombin

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2021 Aug 2

PMID 34335832

Authors

Zhen Lei

Shuibo Gao

Xinzhou Wang

Haixia Gao

Yongjun Han

Zhentao Wang

Hong Wu

Affiliations

Soon will be listed here.

Abstract

Objective: To study the effects of Yiqi Huoxue (YQHX) granules on platelet activation and aggregation induced by thrombin.

Methods: The effect of YQHX on platelet aggregation rate was detected by platelet aggregation instrument; the effect of YQHX on thrombosis time was observed by the mouse mesentery thrombosis model. DAMI cells were induced to transform into platelet-like granules using PMA, and the effects of SCH (PAR-1 inhibitor) on thrombin-induced changes in platelet intracellular calcium concentration, PAR-1 protein expression, and phosphorylation of MAPK were examined.

Results: Compared with the control group, the platelet aggregation rate, PAR-1 protein expression, phosphorylation of ERK1/2, and p38 protein in the YQHX group decreased ( < 0.05), and there was no significant difference between the YQHX + SCH group and YQHX group ( > 0.05).

Conclusion: YQHX suppresses the platelet activation induced by thrombin by inhibiting PAR-1 expression.

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