The Clinical Value of the Combined Detection of Enhanced CT, MRI, CEA, and CA199 in the Diagnosis of Rectal Cancer

Overview

Journal J Oncol

Specialty Oncology

Date 2021 Aug 2

PMID 34335762

Citations 6

Authors

Cuijuan Hao

Yanbin Sui

Jian Li

Yunxia Shi

Zhenxing Zou

Affiliations

Soon will be listed here.

Abstract

Background: To explore the clinical value of enhanced computed tomography (enhanced CT), magnetic resonance imaging (MRI), carcinoembryonic antigen (CEA), and cancer antigen 199 (CA199) in the diagnosis of rectal cancer (RC).

Methods: A total of 156 patients with RC confirmed by postoperative pathology admitted to the Affiliated Yantai Yuhuangding Hospital of Qingdao University from March 2018 to November 2020 were included in the malignant group, and 52 patients with chronic proctitis in the benign control group. All patients underwent preoperative enhanced CT, MRI scans, and serum CEA and CA199 tests. The accuracy, sensitivity, and specificity of single and combined enhanced CT, MRI, CEA, and CA199 tests for the clinical staging of RC were calculated.

Results: The postoperative pathological diagnosis showed that 35 cases of 156 RC patients were at 1 stage, 29 cases were at 2 stage, 24 cases were at 3 stage, 11 cases were at 4 stage, 23 cases were at 0 stage, 21 cases were at 1 stage, 8 cases were at 2 stage, 3 cases were at 0 stage, and 2 cases were at 1 stage. The positive rate of MRI in the diagnosis of RC was higher than that of enhanced CT. Serum CEA and CA199 levels in the malignant group were significantly increased compared with the benign group. The sensitivity, specificity, and accuracy of the combined detection were significantly higher than those of the single detection.

Conclusion: Compared with enhanced CT, MRI has a higher detection rate of and stage in patients with RC. Combined enhanced CT, MRI, CEA, and CA199 can provide more accurate diagnosis and preoperative staging of RC patients.

Citing Articles

Relationship between clinical features and distant metastases in rectal cancer predicted based on a nomogram: a retrospective cohort study.

Jia Q, Li G, Zhang M, Guo M Sci Rep. 2024; 14(1):31219.

PMID: 39732932 PMC: 11682448. DOI: 10.1038/s41598-024-82595-1.

Preoperative prediction of rectal Cancer staging combining MRI deep transfer learning, radiomics features, and clinical factors: accurate differentiation from stage T2 to T3.

Fan L, Wu H, Wu Y, Wu S, Zhao J, Zhu X BMC Gastroenterol. 2024; 24(1):247.

PMID: 39103772 PMC: 11299282. DOI: 10.1186/s12876-024-03316-6.

Value of biplane transrectal ultrasonography plus micro-flow imaging in preoperative T staging and rectal cancer diagnosis in combination with CEA/CA199 and MRI.

Xia Q, Cheng W, Bi J, Ren A, Chen X, Li T BMC Cancer. 2023; 23(1):860.

PMID: 37700269 PMC: 10496222. DOI: 10.1186/s12885-023-11370-8.

The Relationship Between D-dimer and Prognosis in the Patients with Serum Alpha-Fetoprotein-Positive Gastric Cancer: A Retrospective Cohort Study.

Zhang X, Wang W, Tian B, Wang Y, Jing J Clin Med Insights Oncol. 2022; 16:11795549221120158.

PMID: 36104997 PMC: 9465609. DOI: 10.1177/11795549221120158.

A predictive nomogram for lymph node metastasis in part-solid invasive lung adenocarcinoma: A complement to the IASLC novel grading system.

Gao Z, Wang X, Zuo T, Zhang M, Zhang Z Front Oncol. 2022; 12:916889.

PMID: 36046052 PMC: 9423719. DOI: 10.3389/fonc.2022.916889.

References

Teng D, Wu K, Sun Y, Zhang M, Wang D, Wu J . Significant increased CA199 levels in acute pancreatitis patients predicts the presence of pancreatic cancer. Oncotarget. 2018; 9(16):12745-12753. PMC: 5849170. DOI: 10.18632/oncotarget.23993. View

Sao Juliao G, Habr-Gama A, Vailati B, Araujo S, Fernandez L, Perez R . New Strategies in Rectal Cancer. Surg Clin North Am. 2017; 97(3):587-604. DOI: 10.1016/j.suc.2017.01.008. View

Wen X, Wang L, Song X, Zhang Z, Zhu X, Wu S . [Clinical Value of Multi-slice Spiral Enhanced CT in Diagnosing Mild Digestive Tract Hemorrhage]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2018; 40(2):139-145. DOI: 10.3881/j.issn.1000-503X.2018.02.001. View

Timmerman C, Taveras L, Huerta S . Clinical and molecular diagnosis of pathologic complete response in rectal cancer: an update. Expert Rev Mol Diagn. 2018; 18(10):887-896. DOI: 10.1080/14737159.2018.1514258. View

Horvat N, Rocha C, Oliveira B, Petkovska I, Gollub M . MRI of Rectal Cancer: Tumor Staging, Imaging Techniques, and Management. Radiographics. 2019; 39(2):367-387. PMC: 6438362. DOI: 10.1148/rg.2019180114. View

Massihnia D, Pizzutilo E, Amatu A, Tosi F, Ghezzi S, Bencardino K . Liquid biopsy for rectal cancer: A systematic review. Cancer Treat Rev. 2019; 79:101893. DOI: 10.1016/j.ctrv.2019.101893. View

Lindeman N, Cagle P, Aisner D, Arcila M, Beasley M, Bernicker E . Updated Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment With Targeted Tyrosine Kinase Inhibitors: Guideline From the College of American Pathologists, the International Association for the Study of Lung Cancer,.... Arch Pathol Lab Med. 2018; 142(3):321-346. DOI: 10.5858/arpa.2017-0388-CP. View

Hao C, Zhang G, Zhang L . Serum CEA levels in 49 different types of cancer and noncancer diseases. Prog Mol Biol Transl Sci. 2019; 162:213-227. DOI: 10.1016/bs.pmbts.2018.12.011. View

Campos-da-Paz M, Dorea J, Galdino A, Lacava Z, Santos M . Carcinoembryonic Antigen (CEA) and Hepatic Metastasis in Colorectal Cancer: Update on Biomarker for Clinical and Biotechnological Approaches. Recent Pat Biotechnol. 2018; 12(4):269-279. DOI: 10.2174/1872208312666180731104244. View

10.

Balyasnikova S, Brown G . Optimal Imaging Strategies for Rectal Cancer Staging and Ongoing Management. Curr Treat Options Oncol. 2016; 17(6):32. PMC: 4891388. DOI: 10.1007/s11864-016-0403-7. View

11.

Zhang J, Ruan J, Wang W, Lu Y, Wang H, Yu X . Prognostic Value of the Combination of CEA and Fibrinogen/Albumin Ratio in Resectable Gastric Cancer. Cancer Manag Res. 2020; 12:2767-2775. PMC: 7185323. DOI: 10.2147/CMAR.S246566. View

12.

Grunnet M, Sorensen J . Carcinoembryonic antigen (CEA) as tumor marker in lung cancer. Lung Cancer. 2011; 76(2):138-43. DOI: 10.1016/j.lungcan.2011.11.012. View

13.

Mitrogiannis L, Barbouti A, Theodorou E, Kitsouli A, Mitrogiannis G, Kanavaros P . Surgical Treatment of Juvenile Idiopathic Arthritis A Review. Bull Hosp Jt Dis (2013). 2019; 77(2):99-114. View

14.

Keller D, Berho M, Perez R, Wexner S, Chand M . The multidisciplinary management of rectal cancer. Nat Rev Gastroenterol Hepatol. 2020; 17(7):414-429. DOI: 10.1038/s41575-020-0275-y. View

15.

Tian Y, Rong L, Nian W, Wang X, Cai Y, Liu G . [Clinical short-term and long-term efficacy of endoscopic submucosal dissection in the treatment of early low rectal cancer and precancerous lesions]. Zhonghua Wei Chang Wai Ke Za Zhi. 2019; 22(7):639-642. DOI: 10.3760/cma.j.issn.1671-0274.2019.07.007. View

16.

Gurses B, Boge M, Altinmakas E, Balik E . Multiparametric MRI in rectal cancer. Diagn Interv Radiol. 2019; 25(3):175-182. PMC: 6521905. DOI: 10.5152/dir.2019.18189. View

17.

Nasseri Y, Langenfeld S . Imaging for Colorectal Cancer. Surg Clin North Am. 2017; 97(3):503-513. DOI: 10.1016/j.suc.2017.01.002. View

18.

Xu W, Zhang H, Yang X, Bai Y, Lin J, Long J . Prognostic significance of combined preoperative fibrinogen and CA199 in gallbladder cancer patients. World J Gastroenterol. 2018; 24(13):1451-1463. PMC: 5889825. DOI: 10.3748/wjg.v24.i13.1451. View

19.

Wrobel P, Ahmed S . Current status of immunotherapy in metastatic colorectal cancer. Int J Colorectal Dis. 2018; 34(1):13-25. DOI: 10.1007/s00384-018-3202-8. View

20.

Kraege V, Aebischer O, Chocron Y, Bongard C, Moulin V, Schneider A . [The internal medicine articles that struck us the most in 2018]. Rev Med Suisse. 2019; 15(634):146-148. View