Hair Cell Protection from Ototoxic Drugs

Overview

Journal Neural Plast

Specialty Neurology

Date 2021 Aug 2

PMID 34335732

Citations 9

Authors

Peng Wu

Xianmin Wu

Chunhong Zhang

Xiaoyun Chen

Yideng Huang

He Li

Affiliations

Soon will be listed here.

Abstract

Hearing loss is often caused by death of sensory hair cells (HCs) in the inner ear. HCs are vulnerable to some ototoxic drugs, such as aminoglycosides(AGs) and the cisplatin.The most predominant form of drug-induced cell death is apoptosis. Many efforts have been made to protect HCs from cell death after ototoxic drug exposure. These mechanisms and potential targets of HCs protection will be discussed in this review.And we also propose further investigation in the field of HCs necrosis and regeneration, as well as future clinical utilization.

Citing Articles

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