The Effects of Acute Aerobic Exercise on Blood Pressure, Arterial Function, and Heart Rate Variability in Men Living With HIV

Overview

Journal Front Physiol

Date 2021 Aug 2

PMID 34335295

Citations 3

Authors

Juliana Pereira Barros

Tainah de Paula

Mauro Felippe Felix Mediano

Marcus Vinicius Dos Santos Rangel

Walace Monteiro

Felipe Amorim da Cunha

Paulo Farinatti

Juliana Pereira Borges

Affiliations

Soon will be listed here.

Abstract

Purpose: This study aims to investigate the effects of acute cycling on blood pressure (BP), arterial function, and heart rate variability (HRV) in men living with HIV (MLHIV) using combined antiretroviral therapy (cART).

Methods: Twelve MLHIV (48.7 ± 9.2 years; 25.2 ± 2.8 kg m) and 13 healthy controls (41.2 ± 9.9 years; 26.3 ± 2.9 kg m) performed a cycling bout (ES) (intensity: 50% oxygen uptake reserve; duration: time to achieve 150 kcal-MLHIV: 24.1 ± 5.5 vs. controls: 23.1 ± 3.0 min; = 0.45), and a 20-min non-exercise session (NES).

Results: At rest ( < 0.05), MLHIV presented higher brachial systolic/diastolic BP (SBP/DBP: 123.2 ± 14.2/76.8 ± 6.3 vs. 114.3 ± 5.1/71.6 ± 2.6 mmHg) and central BP (cSBP/cDBP: 108.3 ± 9.3/76.5 ± 6.5 vs. 101.6 ± 4.9/71.3 ± 4.4 mmHg) vs. controls but lower absolute maximal oxygen uptake (2.1 ± 0.5 vs. 2.5 ± 0.3 L min) and HRV indices reflecting overall/vagal modulation (SDNN: 24.8 ± 7.1 vs. 42.9 ± 21.3 ms; rMSSD: 20.5 ± 8.5 vs. 38.1 ± 22.8 ms; pNN50: 3.6 ± 4.2 vs. 13.6 ± 11.3%). DBP postexercise lowered in controls vs. MLHIV (∼4 mmHg, < 0.001; ES: 0.6). Moreover, controls vs. MLHIV had greater reductions ( < 0.05) in augmentation index (-13.6 ± 13.7 vs. -3.1 ± 7.2% min; ES: 2.4), and HRV indices up to 5 min (rMSSD: -111.8 ± 32.1 vs. -75.9 ± 22.2 ms min; ES: 3.8; pNN50: -76.3 ± 28.3 vs. -19.0 ± 13.7% min; ES: 4.4). Within-group (ES vs. NES; < 0.05) reductions occurred in controls for SBP (∼10 mmHg, 2 h), DBP (∼6 mmHg, 20, 30, and 70 min), cSBP (∼9 mmHg, 30 min), cDBP (∼7 mmHg, 30 and 70 min), augmentation index (∼10%, 30 min), and pNN50 (∼20%; up to 2 h), while in MLHIV only cSBP (∼6 mmHg, 70 min) and cDBP (∼4 mmHg, 30 min) decreased. Similar increases (up to 5 min) in heart rate (∼22 bpm) and decreases in SDNN (∼18 ms) and rMSSD (∼20 ms) occurred in both groups.

Conclusion: MLHIV under cART exhibited attenuated postexercise hypotension vs. healthy controls, which seemed to relate with impairments in vascular function.

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