Epstein-Barr Virus-positive Intestinal Diffuse Large B-cell Lymphoma in a Japanese Patient with Celiac Disease: First Reported Case and a Literature Review

Overview

Journal Intern Med

Specialty General Medicine

Date 2021 Aug 2

PMID 34334570

Citations 1

Authors

Hideki Ishibashi

So Imakiire

Maki Goto

Ryohei Nomaru

Mamoru Shibata

Hiroki Matsuoka

Hideki Yasuda

Tomomi Yamashima

Hideto Sakisaka

Taro Tanabe

Satoshi Matsuoka

Nobuaki Kuno

Koichi Abe

Sadahiro Funakoshi

Yasushi Takamatsu

Fumihito Hirai

Morishige Takeshita

Affiliations

Soon will be listed here.

Abstract

A 60-year-old Japanese woman was diagnosed with celiac disease (CeD) and treated with a gluten-free diet. For five years, she had a good clinical course. However, she complained of inappetence and nausea. Colonoscopy revealed ulcerative tumors in the terminal ileum. A histological examination of biopsy specimens from the ulcerative tumor showed diffuse infiltration of large atypical lymphocytes. Immunohistologically, the atypical lymphoid cells were positive for cluster of differentiation (CD) 10 and CD20. Many Epstein-Barr virus-encoded small RNA (EBER)-positive atypical lymphocytes were detected by in situ hybridization. This represents the first reported case of Epstein-Barr virus-positive intestinal diffuse large B-cell lymphoma complicated with CeD.

Citing Articles

Primary intestinal diffuse large B-cell lymphoma: novel insights and clinical perception.

Chen X, Wang J, Liu Y, Lin S, Shen J, Yin Y Front Oncol. 2024; 14:1404298.

PMID: 39211552 PMC: 11357906. DOI: 10.3389/fonc.2024.1404298.

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