Cellular Senescence or Stemness: Hypoxia Flips the Coin

Overview

Journal J Exp Clin Cancer Res

Publisher Biomed Central

Specialty Oncology

Date 2021 Jul 30

PMID 34325734

Citations 20

Authors

Daniel Otero-Albiol

Amancio Carnero

Affiliations

Soon will be listed here.

Abstract

Cellular senescence is a complex physiological state whose main feature is proliferative arrest. Cellular senescence can be considered the reverse of cell immortalization and continuous tumor growth. However, cellular senescence has many physiological functions beyond being a putative tumor suppressive trait. It remains unknown whether low levels of oxygen or hypoxia, which is a feature of every tissue in the organism, modulate cellular senescence, altering its capacity to suppress the limitation of proliferation. It has been observed that the lifespan of mammalian primary cells is increased under low oxygen conditions. Additionally, hypoxia promotes self-renewal and pluripotency maintenance in adult and embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs) and cancer stem cells (CSCs). In this study, we discuss the role of hypoxia facilitating senescence bypass during malignant transformation and acquisition of stemness properties, which all contribute to tumor development and cancer disease aggressiveness.

Citing Articles

FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation.

Kong Y, Li Z, Liu Y, Pan B, Fu X, Xiao R Commun Biol. 2025; 8(1):299.

PMID: 39994346 PMC: 11850796. DOI: 10.1038/s42003-025-07738-0.

DNA Damage and Inflammatory Response of p53 Null H358 Non-Small Cell Lung Cancer Cells to X-Ray Exposure Under Chronic Hypoxia.

Nisar H, Brauny M, Labonte F, Schmitz C, Konda B, Hellweg C Int J Mol Sci. 2024; 25(23).

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Hypoxia increases methylated histones to prevent histone clipping and heterochromatin redistribution during Raf-induced senescence.

Chang S, Moon R, Nam D, Lee S, Yoon I, Lee D Nucleic Acids Res. 2024; 53(3).

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Establishment of a novel benign meningioma cell line spontaneously immortalized under hypoxic conditions.

Ishikawa T, Matsuda M, Ishikawa H, Toyomura J, Ohyama A, Sakamoto N Hum Cell. 2024; 38(1):22.

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Investigating the role of senescence biomarkers in colorectal cancer heterogeneity by bulk and single-cell RNA sequencing.

Ding C, Xu X, Zhang X, Zhang E, Li S, Fan X Sci Rep. 2024; 14(1):20083.

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