Revealing the Precise Role of Calretinin Neurons in Epilepsy: We Are on the Way

Overview

Journal Neurosci Bull

Specialty Neurology

Date 2021 Jul 29

PMID 34324145

Citations 10

Authors

Yingbei Qi

Heming Cheng

Yi Wang

Zhong Chen

Affiliations

Soon will be listed here.

Abstract

Epilepsy is a common neurological disorder characterized by hyperexcitability in the brain. Its pathogenesis is classically associated with an imbalance of excitatory and inhibitory neurons. Calretinin (CR) is one of the three major types of calcium-binding proteins present in inhibitory GABAergic neurons. The functions of CR and its role in neural excitability are still unknown. Recent data suggest that CR neurons have diverse neurotransmitters, morphologies, distributions, and functions in different brain regions across various species. Notably, CR neurons in the hippocampus, amygdala, neocortex, and thalamus are extremely susceptible to excitotoxicity in the epileptic brain, but the causal relationship is unknown. In this review, we focus on the heterogeneous functions of CR neurons in different brain regions and their relationship with neural excitability and epilepsy. Importantly, we provide perspectives on future investigations of the role of CR neurons in epilepsy.

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