Small-sized Mesenchymal Stem Cells with High Glutathione Dynamics Show Improved Therapeutic Potency in Graft-versus-host Disease

Overview

Journal Clin Transl Med

Publisher Wiley

Specialty General Medicine

Date 2021 Jul 29

PMID 34323414

Citations 8

Authors

Jisun Lim

Jinbeom Heo

Hwan Yeul Yu

HongDuck Yun

Seungun Lee

Hyein Ju

Yun Ji Nam

Seon Min Jeong

Jinwon Lee

You Sook Cho

Myung-Soo Choo

Eui Man Jeong

Chae-Min Ryu

Dong-Myung Shin

Affiliations

Soon will be listed here.

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Mesenchymal stem cells with an enhanced antioxidant capacity integrate as smooth muscle cells in a model of diabetic detrusor underactivity.

Ryu C, Kim Y, Shin J, Lee S, Ju H, Nam Y Clin Transl Med. 2024; 14(10):e70052.

PMID: 39390754 PMC: 11467036. DOI: 10.1002/ctm2.70052.

Assessment of the Therapeutic Effectiveness of Glutathione-Enhanced Mesenchymal Stem Cells in Rat Models of Chronic Bladder Ischemia-Induced Overactive Bladder and Detrusor Underactivity.

Shin J, Yu H, Kwon H, Yun H, Ryu C, Shin D Int J Stem Cells. 2024; 18(1):72-86.

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Highly efficient genome editing via CRISPR-Cas9 ribonucleoprotein (RNP) delivery in mesenchymal stem cells.

Han A, Shin H, Kwon J, Lee S, Lee S, Kim E BMB Rep. 2023; 57(1):60-65.

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Glutathione dynamics is a potential predictive and therapeutic trait for neoadjuvant chemotherapy response in bladder cancer.

Kim Y, Ju H, Yoo S, Jeong J, Heo J, Lee S Cell Rep Med. 2023; 4(10):101224.

PMID: 37797616 PMC: 10591055. DOI: 10.1016/j.xcrm.2023.101224.

References

Kim Y, Jin H, Heo J, Ju H, Lee H, Kim S . Small hypoxia-primed mesenchymal stem cells attenuate graft-versus-host disease. Leukemia. 2018; 32(12):2672-2684. PMC: 6286327. DOI: 10.1038/s41375-018-0151-8. View

Jeong E, Yoon J, Lim J, Shin J, Cho A, Heo J . Real-Time Monitoring of Glutathione in Living Cells Reveals that High Glutathione Levels Are Required to Maintain Stem Cell Function. Stem Cell Reports. 2018; 10(2):600-614. PMC: 5830891. DOI: 10.1016/j.stemcr.2017.12.007. View

Gao L, Zhang Y, Hu B, Liu J, Kong P, Lou S . Phase II Multicenter, Randomized, Double-Blind Controlled Study of Efficacy and Safety of Umbilical Cord-Derived Mesenchymal Stromal Cells in the Prophylaxis of Chronic Graft-Versus-Host Disease After HLA-Haploidentical Stem-Cell Transplantation. J Clin Oncol. 2016; 34(24):2843-50. DOI: 10.1200/JCO.2015.65.3642. View

Heo J, Lim J, Lee S, Jeong J, Kang H, Kim Y . Sirt1 Regulates DNA Methylation and Differentiation Potential of Embryonic Stem Cells by Antagonizing Dnmt3l. Cell Rep. 2017; 18(8):1930-1945. DOI: 10.1016/j.celrep.2017.01.074. View

Lee S, Lim J, Lee J, Ju H, Heo J, Kim Y . Ascorbic Acid 2-Glucoside Stably Promotes the Primitiveness of Embryonic and Mesenchymal Stem Cells Through Ten-Eleven Translocation- and cAMP-Responsive Element-Binding Protein-1-Dependent Mechanisms. Antioxid Redox Signal. 2019; 32(1):35-59. DOI: 10.1089/ars.2019.7743. View