Human Immune Repertoire in Hepatitis B Virus Infection

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2021 Jul 29

PMID 34321844

Citations 6

Authors

Qiao Zhan

Jing-Hang Xu

Yan-Yan Yu

Emily Lo Kk

Hani El-Nezami

Zheng Zeng

Affiliations

Soon will be listed here.

Abstract

Hepatitis B virus (HBV) infection is a public health threat that affects 257 million people worldwide and can progress to liver cirrhosis, liver failure, and hepatocellular carcinoma. The HBV antigen- induced adaptive immune response plays an important role in HBV clearance. Immune repertoire sequencing (IRS) has been used to investigate the molecular mechanisms behind the immune system, find novel ways to treat HBV infection, and evaluate the genetic responses and immune characteristics of individuals infected by HBV or immunized by HBV vaccine. This review summarizes the human immune repertoire analysis methodology, and the application of the IRS in the prediction of HBV infection progression, treatment, and vaccination.

Citing Articles

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