Examining the Causal Mediating Role of Brain Pathology on the Relationship Between Diabetes and Cognitive Impairment: the Cardiovascular Health Study

Overview

Journal J R Stat Soc Ser A Stat Soc

Publisher Oxford University Press

Specialty Public Health

Date 2021 Jul 29

PMID 34321718

Citations 4

Authors

Ryan M Andrews

Ilya Shpitser

Oscar Lopez

William T Longstreth

Paulo H M Chaves

Lewis Kuller

Michelle C Carlson

Affiliations

Soon will be listed here.

Abstract

The paper examines whether leads to incident mild cognitive impairment and dementia through brain hypoperfusion and white matter disease. We performed inverse odds ratio weighted causal mediation analyses to decompose the effect of diabetes on cognitive impairment into direct and indirect effects, and we found that approximately a third of the total effect of diabetes is mediated through vascular-related brain pathology. Our findings lend support for a common aetiological hypothesis regarding incident cognitive impairment, which is that diabetes increases the risk of clinical cognitive impairment in part by impacting the vasculature of the brain.

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