PfHRP2 Detection Using Plasmonic Optrodes: Performance Analysis

Overview

Journal Malar J

Publisher Biomed Central

Specialty Tropical Medicine

Date 2021 Jul 29

PMID 34320995

Citations 5

Authors

Mederic Loyez

Mathilde Wells

Stephanie Hambye

Francois Hubinon

Bertrand Blankert

Ruddy Wattiez

Christophe Caucheteur

Affiliations

Soon will be listed here.

Abstract

Background: Early malaria diagnosis and its profiling require the development of new sensing platforms enabling rapid and early analysis of parasites in blood or saliva, aside the widespread rapid diagnostic tests (RDTs).

Methods: This study shows the performance of a cost-effective optical fiber-based solution to target the presence of Plasmodium falciparum histidine-rich protein 2 (PfHRP2). Unclad multimode optical fiber probes are coated with a thin gold film to excite Surface Plasmon Resonance (SPR) yielding high sensitivity to bio-interactions between targets and bioreceptors grafted on the metal surface.

Results: Their performances are presented in laboratory conditions using PBS spiked with growing concentrations of purified target proteins and within in vitro cultures. Two probe configurations are studied through label-free detection and amplification using secondary antibodies to show the possibility to lower the intrisic limit of detection.

Conclusions: As malaria hits millions of people worldwide, the improvement and multiplexing of this optical fiber technique can be of great interest, especially for a future purpose of using multiple receptors on the fiber surface or several coated-nanoparticles as amplifiers.

Citing Articles

Dual-Mode Comb Plasmonic Optical Fiber Sensing.

Villatoro E, Loyez M, Villatoro J, Caucheteur C, Albert J ACS Sens. 2024; 9(6):3027-3036.

PMID: 38864606 PMC: 11218750. DOI: 10.1021/acssensors.4c00229.

Detection of NT-proBNP Using Optical Fiber Back-Reflection Plasmonic Biosensors.

Assuncao A, Vidal M, Martins M, Girao A, Loyez M, Caucheteur C Biosensors (Basel). 2024; 14(4).

PMID: 38667166 PMC: 11048293. DOI: 10.3390/bios14040173.

Aptamer-Based Technologies for Parasite Detection.

Brosseau N, Vallee I, Mayer-Scholl A, Ndao M, Karadjian G Sensors (Basel). 2023; 23(2).

PMID: 36679358 PMC: 9867382. DOI: 10.3390/s23020562.

Review of Microdevices for Hemozoin-Based Malaria Detection.

Baptista V, Peng W, Minas G, Veiga M, Catarino S Biosensors (Basel). 2022; 12(2).

PMID: 35200370 PMC: 8870200. DOI: 10.3390/bios12020110.

Recent Advances in Biomedical Photonic Sensors: A Focus on Optical-Fibre-Based Sensing.

Ochoa M, Algorri J, Roldan-Varona P, Rodriguez-Cobo L, Lopez-Higuera J Sensors (Basel). 2021; 21(19).

PMID: 34640788 PMC: 8513032. DOI: 10.3390/s21196469.

References

Monfared Y . Overview of Recent Advances in the Design of Plasmonic Fiber-Optic Biosensors. Biosensors (Basel). 2020; 10(7). PMC: 7400712. DOI: 10.3390/bios10070077. View

Lu J, Van Stappen T, Spasic D, Delport F, Vermeire S, Gils A . Fiber optic-SPR platform for fast and sensitive infliximab detection in serum of inflammatory bowel disease patients. Biosens Bioelectron. 2015; 79:173-9. DOI: 10.1016/j.bios.2015.11.087. View

Loyez M, Hassan E, Lobry M, Liu F, Caucheteur C, Wattiez R . Rapid Detection of Circulating Breast Cancer Cells Using a Multiresonant Optical Fiber Aptasensor with Plasmonic Amplification. ACS Sens. 2020; 5(2):454-463. DOI: 10.1021/acssensors.9b02155. View

Jimenez A, Rees-Channer R, Perera R, Gamboa D, Chiodini P, Gonzalez I . Analytical sensitivity of current best-in-class malaria rapid diagnostic tests. Malar J. 2017; 16(1):128. PMC: 5366122. DOI: 10.1186/s12936-017-1780-5. View

Deraney R, Mace C, Rolland J, Schonhorn J . Multiplexed, Patterned-Paper Immunoassay for Detection of Malaria and Dengue Fever. Anal Chem. 2016; 88(12):6161-5. DOI: 10.1021/acs.analchem.6b00854. View

Bremer K, Roth B . Fibre optic surface plasmon resonance sensor system designed for smartphones. Opt Express. 2015; 23(13):17179-84. DOI: 10.1364/OE.23.017179. View

Bandyopadhyay S, Biswas P, Chiavaioli F, Dey T, Basumallick N, Trono C . Long-period fiber grating: a specific design for biosensing applications. Appl Opt. 2017; 56(35):9846-9853. DOI: 10.1364/AO.56.009846. View

Loyez M, Lobry M, Hassan E, DeRosa M, Caucheteur C, Wattiez R . HER2 breast cancer biomarker detection using a sandwich optical fiber assay. Talanta. 2020; 221:121452. DOI: 10.1016/j.talanta.2020.121452. View

Fung A, Damoiseaux R, Grundeen S, Panes J, Horton D, Judy J . Quantitative detection of PfHRP2 in saliva of malaria patients in the Philippines. Malar J. 2012; 11:175. PMC: 3422183. DOI: 10.1186/1475-2875-11-175. View

10.

Lobry M, Loyez M, Chah K, Hassan E, Goormaghtigh E, DeRosa M . HER2 biosensing through SPR-envelope tracking in plasmonic optical fiber gratings. Biomed Opt Express. 2020; 11(9):4862-4871. PMC: 7510885. DOI: 10.1364/BOE.401200. View

11.

Reimhult K, Petersson K, Krozer A . QCM-D analysis of the performance of blocking agents on gold and polystyrene surfaces. Langmuir. 2008; 24(16):8695-700. DOI: 10.1021/la800224s. View

12.

Mishra M, Mishra V, Kashaw V, Iyer A, Kashaw S . Comprehensive review on various strategies for antimalarial drug discovery. Eur J Med Chem. 2016; 125:1300-1320. DOI: 10.1016/j.ejmech.2016.11.025. View

13.

Peeters B, Safdar S, Daems D, Goos P, Spasic D, Lammertyn J . Solid-Phase PCR-Amplified DNAzyme Activity for Real-Time FO-SPR Detection of the MCR-2 Gene. Anal Chem. 2020; 92(15):10783-10791. DOI: 10.1021/acs.analchem.0c02241. View

14.

Lobry M, Loyez M, Hassan E, Chah K, DeRosa M, Goormaghtigh E . Multimodal plasmonic optical fiber grating aptasensor. Opt Express. 2020; 28(5):7539-7551. DOI: 10.1364/OE.385747. View

15.

Horta S, Qu J, Dekimpe C, Bonnez Q, Vandenbulcke A, Tellier E . Co(III)-NTA Mediated Antigen Immobilization on a Fiber Optic-SPR Biosensor for Detection of Autoantibodies in Autoimmune Diseases: Application in Immune-Mediated Thrombotic Thrombocytopenic Purpura. Anal Chem. 2020; 92(20):13880-13887. DOI: 10.1021/acs.analchem.0c02586. View

16.

Daems D, Peeters B, Delport F, Remans T, Lammertyn J, Spasic D . Identification and Quantification of Celery Allergens Using Fiber Optic Surface Plasmon Resonance PCR. Sensors (Basel). 2017; 17(8). PMC: 5579924. DOI: 10.3390/s17081754. View

17.

Loyez M, Larrieu J, Chevineau S, Remmelink M, Leduc D, Bondue B . In situ cancer diagnosis through online plasmonics. Biosens Bioelectron. 2019; 131:104-112. DOI: 10.1016/j.bios.2019.01.062. View

18.

Ribaut C, Loyez M, Larrieu J, Chevineau S, Lambert P, Remmelink M . Cancer biomarker sensing using packaged plasmonic optical fiber gratings: Towards in vivo diagnosis. Biosens Bioelectron. 2016; 92:449-456. DOI: 10.1016/j.bios.2016.10.081. View

19.

Lillehoj P, Huang M, Truong N, Ho C . Rapid electrochemical detection on a mobile phone. Lab Chip. 2013; 13(15):2950-5. DOI: 10.1039/c3lc50306b. View

20.

Qu J, Dillen A, Saeys W, Lammertyn J, Spasic D . Advancements in SPR biosensing technology: An overview of recent trends in smart layers design, multiplexing concepts, continuous monitoring and in vivo sensing. Anal Chim Acta. 2020; 1104:10-27. DOI: 10.1016/j.aca.2019.12.067. View