Morphological Lesion Types Are Associated with Primary and Secondary Patency Rates After High-Pressure Balloon Angioplasty for Dysfunctional Arteriovenous Fistulas

Overview

Journal Blood Purif

Specialty Hematology

Date 2021 Jul 28

PMID 34320498

Citations 3

Authors

Li Chen

Weichen Zhang

Jinyun Tan

Min Hu

Weihao Shi

Minmin Zhang

Yong Wang

Bo Yu

Jing Chen

Affiliations

Soon will be listed here.

Abstract

Background: Neointimal hyperplasia (NIH) is believed to be the main reason for arteriovenous fistula (AVF) dysfunction, but other mechanisms are also recognized to be involved in the pathophysiological process. This study investigated whether different morphological types of AVF lesions are associated with the patency rate after percutaneous transluminal angioplasty (PTA).

Methods: This retrospective study included 120 patients who underwent PTA for autogenous AVF dysfunction. All the cases were evaluated under Doppler ultrasound (DU) before intervention and divided into 3 types: Type I (NIH type), Type II (non-NIH type), and Type III (mixed type). Prognostic and clinical data were analyzed by Kaplan-Meier analysis and the Cox proportional hazards model.

Results: There was no statistical difference in baseline variables among groups, except for lumen diameter. The primary patency rates in Type I, Type II, and Type III groups were 78.4, 93.2, and 83.2% at 6 months and 59.5, 84.7, and 75.5% at 1 year, respectively. The secondary patency rates in Type I, Type II, and Type III groups were 94.4, 97.1, and 100% at 6 months and 90.5, 97.1, and 94.7% at 1 year, respectively. The Kaplan-Meier curve showed that the primary and secondary patency rates of Type I group were lower than those of Type II group. Multivariable Cox regression analysis demonstrated that postoperative primary patency was correlated with end-to-end anastomosis (hazard ratio [HR] = 2.997, p = 0.008, 95% confidence interval [CI]: 1.328-6.764) and Type I lesion (HR = 5.395, p = 0.004, 95% CI: 1.730-16.824).

Conclusions: NIH-dominant lesions of AVF evaluated by DU preoperatively were a risk factor for poor primary and secondary patency rate after PTA in hemodialysis patients.

Citing Articles

Long-Term Efficacy of Ultrasound-Guided Percutaneous Transluminal Angioplasty for Arteriovenous Fistula Outflow Stenosis Caused by Venous Valve.

Chen B, Chen L, Yang Q, Gao X, Lai Q, Tu B Kidney Dis (Basel). 2024; 10(2):89-96.

PMID: 38751797 PMC: 11095604. DOI: 10.1159/000536309.

Comparison of ultrasound features and lesion sites in dysfunctional arteriovenous fistula.

Wang Y, Huang X, Zhang Y, Li J, Li J, Ye Z Ren Fail. 2024; 46(1):2294148.

PMID: 38186351 PMC: 10776081. DOI: 10.1080/0886022X.2023.2294148.

Factors affecting the primary patency of native arteriovenous fistulas after ultrasound-guided percutaneous transluminal angioplasty.

Xing X, Li Q, Yang Y, Wang Y, Zhan X, Zhang C Ren Fail. 2023; 45(1):2233623.

PMID: 37488970 PMC: 10373618. DOI: 10.1080/0886022X.2023.2233623.

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