» Articles » PMID: 34316655

Deep Brain Stimulation Targeting the Globus Pallidus Internus for Parkinson's Disease and Tourette Syndrome

Overview
Date 2021 Jul 28
PMID 34316655
Authors
Affiliations
Soon will be listed here.
Abstract

We present a case with co-existing Parkinson's disease and Tourette syndrome. Patient takes aripiprazole for Tourette syndrome, which unfortunately worsens his parkinsonian symptoms. We placed deep brain stimulation targeting the Globus pallidus internus. Strikingly, his parkinsonian motor symptoms and his tics are both well controlled with deep brain stimulation.

References
1.
Pieters L, Bakker P, van Harten P . Asymmetric Drug-Induced Parkinsonism and Psychopathology: A Prospective Naturalistic Study in Long-Stay Psychiatric Patients. Front Psychiatry. 2018; 9:18. PMC: 5807329. DOI: 10.3389/fpsyt.2018.00018. View

2.
Shahed J, Poysky J, Kenney C, Simpson R, Jankovic J . GPi deep brain stimulation for Tourette syndrome improves tics and psychiatric comorbidities. Neurology. 2007; 68(2):159-60. DOI: 10.1212/01.wnl.0000250354.81556.90. View

3.
Patel N, Jimenez-Shahed J . Simultaneous improvement of tics and parkinsonism after pallidal DBS. Parkinsonism Relat Disord. 2014; 20(9):1022-3. DOI: 10.1016/j.parkreldis.2014.05.009. View

4.
Lopez-Torres E, Salomon J, Vicario F, Penas-Lledo E, Dorado P, LLerena A . Aripiprazole-induced parkinsonism and its association with dopamine and serotonin receptor polymorphisms. J Clin Psychopharmacol. 2008; 28(3):352-3. DOI: 10.1097/JCP.0b013e318172757f. View

5.
Sharma A, Sorrell J . Aripiprazole-induced parkinsonism. Int Clin Psychopharmacol. 2006; 21(2):127-9. DOI: 10.1097/01.yic.0000185025.40656.30. View