Micromanaging Pattern Formation: MiRNA Regulation of Signaling Systems in Vertebrate Development

Overview

Journal FEBS J

Specialty Biochemistry

Date 2021 Jul 26

PMID 34310060

Citations 3

Authors

Jacqueline Copeland

Kayla Wilson

Marcos Simoes-Costa

Affiliations

Soon will be listed here.

Abstract

Early embryogenesis requires the establishment of fields of progenitor cells with distinct molecular signatures. A balance of intrinsic and extrinsic cues determines the boundaries of embryonic territories and pushes progenitor cells toward different fates. This process involves multiple layers of regulation, including signaling systems, transcriptional networks, and post-transcriptional control. In recent years, microRNAs (miRNAs) have emerged as undisputed regulators of developmental processes. Here, we discuss how miRNAs regulate pattern formation during vertebrate embryogenesis. We survey how miRNAs modulate the activity of signaling pathways to optimize transcriptional responses in embryonic cells. We also examine how localized RNA interference can generate spatial complexity during early development. Unraveling the complex crosstalk between miRNAs, signaling systems and cell fate decisions will be crucial for our understanding of developmental outcomes and disease.

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